… The rhesus macaque TRIM5α protein blocks HIV-1 through a … between the TRIM5α SPRY
domain and the HIV-1 capsid. … as a trimer that is similar in structure to the TRIM5α B-box trimer. …

… by recognition of and binding to the retroviral capsid. Human … of the β-sheet barrel on SPRY
structure of TRIM5α. Furthermore, the … TRIM5α restricts HIV-1 infection in Old World monkeys. …

… ) domain that is required for capsid recognition: SPRY (also … -coated capsid, assembled
from crystal structures of the HIV-1 … the isolated SPRY domain of rhesus monkey TRIM5α and a …

… Capsid recognition is mediated by C-terminal domains on TRIM5α (SPRY) or TRIMCyp (…
To characterize how TRIM5 proteins recognize viral capsids, we developed methods for …

… structures of TRIM5 domain fragments (8). Our maps also provide direct experimental
evidence that the two SPRY domains of a TRIM5α … SPRY domain of rhesus macaque TRIM5α …

… host and HIV-1 CA, with many parallels to Mx2 is that for the SPRY domain of TRIM5α, which
… TRIM5α restriction is dependent on viral capsid recognition and assembly mediated by the …

… the incoming capsid cores of retroviruses such as HIV and … Published structures of the TRIM5α
SPRY domain have … Interestingly, the relative spacings of interaction modules have been …

… The honeycomb-like structures of TRIM5α matches the … that rhesus macaque monkeys are
resistant to HIV infection due to a … of TRIM5α lies the SPRY domain, the portion of TRIM5α that …

… the SPRY domains to interact with repeating structural … TRIMCyp is a related RBCC
protein found in owl monkeys … the SPRY domain, host cells seem to have adapted a modular …

… factor Trim5α, that blocks HIV-1 infection in rhesus macaques … of a single PRY/SPRY domain
for capsid protein Trim5α self-… Structure of the rhesus monkey TRIM5α PRYSPRY domain, …