Background Deep brain stimulation (DBS) of the subcallosal cingulate white matter has
shown promise as an intervention for patients with chronic, unremitting depression. To test
the safety and efficacy of DBS for treatment-resistant depression, a prospective, randomised,
sham-controlled trial was conducted. Methods Participants with treatment-resistant
depression were implanted with a DBS system targeting bilateral subcallosal cingulate white
matter and randomised to 6 months of active or sham DBS, followed by 6 months of open …

Background Deep brain stimulation (DBS) is considered a relatively new and still
experimental therapeutic modality for treatment-resistant depression (TRD). There is clinical
evidence to suggest that stimulation of the subcallosal cingulate cortex (SCC) involved in the
pathogenesis of TRD may exert an antidepressant effect. Aims To conduct a systematic
review of current studies, such as randomized clinical trials (RCTs), open-label trials, and
placebo-controlled trials, examining SCC DBS for TRD in human participants. Method A …