Mucus concentration–dependent biophysical abnormalities unify submucosal gland and superficial airway dysfunction in cystic fibrosis
… submucosal gland (SMG) dysfunction to the proximal airway features of CF lung disease.
Studies in CF pig tracheas described secretion … are postulated to adhere to proximal CF airway …
Studies in CF pig tracheas described secretion … are postulated to adhere to proximal CF airway …
[HTML][HTML] Acidic submucosal gland pH and elevated protein concentration produce abnormal cystic fibrosis mucus
… insults, airway submucosal glands … cystic fibrosis, stimulating submucosal glands has the
opposite effect, disrupting mucociliary transport. In cystic fibrosis (CF) pigs, loss of cystic fibrosis …
opposite effect, disrupting mucociliary transport. In cystic fibrosis (CF) pigs, loss of cystic fibrosis …
[HTML][HTML] Progress in understanding mucus abnormalities in cystic fibrosis airways
… in the upper airways: 1) secretion by submucosal glands; 2) secretion by surface epithelia;
3… and 5) airway diameter. Increases of the first 3 and decreases in absorption are predicted to …
3… and 5) airway diameter. Increases of the first 3 and decreases in absorption are predicted to …
Airway submucosal glands from cystic fibrosis swine suffer from abnormal ion transport across the serous acini, collecting duct, and ciliated duct
… their secretions and why they are abnormal in CF, we need … wild-type airway submucosal
glands with the cAMP-elevating … agonist carbachol activated Na + and Cl − secretion by the …
glands with the cAMP-elevating … agonist carbachol activated Na + and Cl − secretion by the …
Mucin secretion in cystic fibrosis: a systematic review
… chloride secretion, the function of epithelial sodium channel, … in the lungs and intestinal
tract of CF patients. Understanding … in the submucosal glands of airways in CF patients when …
tract of CF patients. Understanding … in the submucosal glands of airways in CF patients when …
[HTML][HTML] Development of an airway mucus defect in the cystic fibrosis rat
SE Birket, JM Davis, CM Fernandez, KL Tuggle… - JCI insight, 2018 - ncbi.nlm.nih.gov
… secretions are mature, lending a crucial insight into the role of submucosal glands in the
development of CF airway … We found that sodium bicarbonate added at any pH increased MCT …
development of CF airway … We found that sodium bicarbonate added at any pH increased MCT …
[HTML][HTML] Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways
LH Abdullah, JR Evans, TT Wang, AA Ford… - JCI insight, 2017 - ncbi.nlm.nih.gov
… gland secretion (26, 28). This model mimics the CF condition by … mucin secretion from the
mucous cells of the submucosal glands … of liquid secretion in bronchial airways than Na + /H + …
mucous cells of the submucosal glands … of liquid secretion in bronchial airways than Na + /H + …
Mucus, mucins, and cystic fibrosis
… secretion via the CFTR channel and increased sodium … airways and submucosal glands
located in the large airways.… stimulation of submucosal gland secretion with methacholine…
located in the large airways.… stimulation of submucosal gland secretion with methacholine…
Airway mucus hyperconcentration in non–cystic fibrosis bronchiectasis
KA Ramsey, ACH Chen, G Radicioni… - American journal of …, 2020 - atsjournals.org
… airway epithelia (Figure E2A). MUC5AC protein was not detected in the submucosal glands
of the … between active airway transepithelial Na + absorption versus Cl − secretion that would …
of the … between active airway transepithelial Na + absorption versus Cl − secretion that would …
Unplugging mucus in cystic fibrosis and chronic obstructive pulmonary disease
MA Mall - Annals of the American Thoracic Society, 2016 - atsjournals.org
… CF identified airway surface dehydration due to cystic fibrosis transmembrane … in secretion
of these anions and fluid by epithelia lining the conducting airways and submucosal glands (…
of these anions and fluid by epithelia lining the conducting airways and submucosal glands (…