Neuropeptide regulation of secretion and inflammation in human airway gland serous cells

…, CCL Tong, P Papagiannopoulos… - European …, 2020 - Eur Respiratory Soc
… that defects in CFTR-dependent serous secretion contribute to … also secrete HCO 3 − during
VIP stimulation, if this occurs … cell surrogate, secrete HCO 3 − mainly through CFTR while Cl …

[HTML][HTML] Role of CFTR in epithelial physiology

V Saint-Criq, MA Gray - Cellular and Molecular Life Sciences, 2017 - Springer
… was CFTR-dependent but that although fluid secretion was mainly mediated through
CFTR, … stimulates NaCl and fluid secretion, as well the regulated exocytosis of enzyme-containing …

[HTML][HTML] Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis

KR Atanasova, LR Reznikov - Respiratory Research, 2018 - Springer
… ) gene – the parent of Substance P (SubP) and neurokinin A (… Their effects are mediated
via NK1 receptors (mainly for … SubP stimulates gland secretion in “normal” submucosal glands

Inverse regulation of secretion and inflammation in human airway gland serous cells by neuropeptides upregulated in allergy and asthma

…, MA Kohanski, CCL Tong, P Papagiannopoulos… - bioRxiv, 2019 - biorxiv.org
… Defects in CFTR-dependent serous cell secretion likely play an … acinar cells secrete
HCO 3 − during stimulation with VIP, … VIP and NPY, but not substance P or calcitonin gene-related …

Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs

W Yu, TO Moninger, AL Thurman… - Proceedings of the …, 2022 - National Acad Sciences
… genes were not well aligned to reference genes, primarily because of the lack of 3′ …
substance P causes rapid cell shrinkage, an assay of anion secretions, and at the end of stimulation

[PDF][PDF] Effect of Bacteria on Airway Submucosal Glands Liquid Secretion in Swine

XJ Luan - 2018 - harvest.usask.ca
substance P Temp … that inhalation of bacteria triggers CFTR-dependent ASL secretion. We
suggest that … with PAK stimulated significantly greater submucosal gland secretion than the …

[HTML][HTML] The potential role and regulatory mechanisms of MUC5AC in chronic obstructive pulmonary disease

J Li, Z Ye - Molecules, 2020 - mdpi.com
… MUC5AC is mainly secreted by the goblet airway epithelium, … NCI-H292 cells and sulfur
dioxide-stimulated rat bronchitis … by activating wild-type CFTR-dependent, short circuit current …

PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition by Pseudomonas aeruginosa

DB McMahon, RM Carey… - … of Physiology-Lung …, 2021 - journals.physiology.org
… in response to PAR-2 stimulation using Ca 2+ imaging and … of synergistic CFTR-dependent
PAR-2/VIPR secretion may … In contrast to mice, fluid secretion is largely intact when the …

CHANGES IN VASOACTIVE INTESTINAL PEPTIDE (VIP) AMOUNT IN CYSTIC FIBROSIS

P Semaniakou - 2020 - dalspace.library.dal.ca
… and submucosal glands of the conducting airways, stimulating … , fluid secretion from serous
cells is CFTR-dependent while … in response to ACh, VIP, substance P (SP) and nitric oxide …

The role of vasoactive intestinal peptide in pulmonary diseases

HL Zhong, PZ Li, D Li, CX Guan, Y Zhou - Life Sciences, 2023 - Elsevier
… Effects on TNF-α, IL-10, IL-12, and NO are mainly mediated throughCFTR-dependent
secretion is influenced by VIP. One study has previously disclosed that VIP triggers the stimulation