Intestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets

X Zhou, Y Liu, X Xiong, J Chen, W Tang, L He… - Gut …, 2022 - Taylor & Francis
… a pig model of post-weaning stress-induced diarrhea, we … diarrhea and suggest that colonic
accumulation of microbiota-produced succinate caused by loss of miRNAs leads to diarrhea

The role of succinate in the regulation of intestinal inflammation

J Connors, N Dawe, J Van Limbergen - Nutrients, 2018 - mdpi.com
Succinate is also produced in large amounts during bacterial … Studies in pigs with
antibiotic-induced diarrhea (AAD) … —a leading cause of antibiotic-associated diarrhea—has also …

Succinate communicates pro-inflammatory signals to the host and regulates bile acid enterohepatic metabolism in a pig model

X Li, Y Ren, G Huang, R Zhang, Y Zhang, W Zhu… - Food & Function, 2022 - pubs.rsc.org
… Thus, accumulated endogenous succinate is traditionally … Using the pig small intestine cell
line IPI-2I, we firstly found … in humans 9 and antibiotic-induced diarrhea in pigs, 22 and it is …

Limosilactobacillus mucosae-derived extracellular vesicles modulates macrophage phenotype and orchestrates gut homeostasis in a diarrheal piglet model

J Li, S Feng, Z Wang, J He, Z Zhang, H Zou… - npj Biofilms and …, 2023 - nature.com
… the duration of acute diarrhea and hospitalization for acute gastroenteritis, but does not
seem to prevent nosocomial diarrhea or antibiotic-associated diarrhea 79 , indicating that even …

Effects of Actigen, a second-generation mannan rich fraction, in antibiotics-free diets on growth performance, intestinal barrier functions and inflammation in weaned …

M Song, Y Fan, H Su, J Ye, F Liu, X Zhu, L Wang… - Livestock Science, 2019 - Elsevier
… One problem is antibiotic-associated diarrhea, which may … of diarrhea =total number of pigs
with diarrhea observed each … Equal protein amounts of each sample were separated by SDS…

Antibiotic-induced gut dysbiosis and barrier disruption and the potential protective strategies

H Duan, L Yu, F Tian, Q Zhai, L Fan… - Critical reviews in food …, 2022 - Taylor & Francis
… the characteristics of antibiotic-associated gut dysbiosis and … it was absorbed mainly in the
small intestine and little of the … antibiotic therapy consume sufficient amounts of probiotics (…

[HTML][HTML] Extracellular succinate induces spatially organized biofilm formation in Clostridioides difficile

E Auria, J Deschamps, R Briandet, B Dupuy - Biofilm, 2023 - Elsevier
… the leading cause of nosocomial diarrhea and colitis in industrialized … In addition, pigs treated
with antibiotics showed a … the presence of succinate with decreasing amounts of glucose in …

Disruption of the primocolonizing microbiota alters epithelial homeostasis and imprints stem cells in the colon of neonatal piglets

M Beaumont, C Lencina, K Fève, C Barilly… - The FASEB …, 2023 - Wiley Online Library
Succinate accumulation in pig large intestine during antibiotic- associated diarrhea and
the constitution of succinate- producing flora. J Gen Appl Microbiol. 2002;48:143- 154. …

Clostridium difficile, the Difficult “Kloster” Fuelled by Antibiotics

LMT Dicks, LS Mikkelsen, E Brandsborg… - Current microbiology, 2019 - Springer
… Symptoms of infection varies from mild diarrhea to colitis (associated with dehydration and …
The large intestine is lacking free glucose [9], but contains adequate amounts of amino acids. …

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

W Lei, W Ren, M Ohmoto, JF Urban Jr… - Proceedings of the …, 2018 - National Acad Sciences
… Tsukahara and Ushida (24) showed that in pig large intestine, succinate accumulates during
antibiotic-associated diarrhea and that there are changes in the constitution of succinate-…