… Houessinon et al. reported a patient with clival chordoma who showed a partial response
and a sustained benefit for more than 28 months with erlotinib [19]. Our patient showed a …

… in one case of clivus chordoma treated with imatinib (36). … with erlotinib (NCT00739453) (22).
One patient with … regimen of everolimus and imatinib resulted in sustained SD in one patient…

… erlotinib induced a symptomatic and radiological response (>30% reduction in tumour bulk)
in a patient with an imatinib-resistant chordoma … and symptomatic problems which it gives …

… suggest response to erlotinib after development of imatinib-… had a partial and sustained
response lasting longer than 28 … study failed to meet its primary endpoint of a 30% response …

… Indeed, a sustained response to erlotinib of a clivus-arising chordoma after imatinib failure
… Our case report shows no clear clinical response to erlotinib in an imatinib-refractory sacral …

… /case reports have explored targeted therapies such as imatinib, dasatinib, everolimus, and
… of chordoma patients leading to a phase II trial with imatinib. There was a modest response …

… imatinib-resistant chordomas (one with a clival chordoma) … The phase I trials of gefitinib with
irinotecan [127] and erlotinib … disease stabilization, maintained responses are anecdotal with …

… Clival and base of skull conventional chordoma, though … in imatinib-resistant chordoma in
vitro, the combination of … , and erlotinib, with monotherapy or combination, have shown partial …

… of six pediatric patients with clival chordomas, Dhall et al. … treated with imatinib demonstrated
a partial response, as … inhibitors of EGFR, including erlotinib and gefitinib, as well as …

… The occurrence of objective response and imatinib or erlotinib use were associated with …
the devastating impact of local persistent disease. Most advanced chordomas (AC) display an …