… loss of synapses is fundamental to healthy brain function. While Alzheimer’s Disease (AD) …
protein pathologies, the synapse itself may also be a critical endpoint to consider regarding …

… This article aims to address the mechanisms of synaptic degeneration in AD and discuss
current strategies that focus on the synapse for AD therapy. Alzheimer’s disease (AD) is a …

… we now call synapses [151] and Alzheimer … synapses were lost or damaged in Alzheimer’s
disease (AD) was first reported in the 1980s and since then studies have shown that synapse …

… tau are hallmark lesions of Alzheimer’s disease (AD). However, the loss of synapses and
dysfunctions of neurotransmission are more directly tied to disease severity. The role of these …

… Alzheimer’s disease (AD) is a devastating neurodegenerative disorder … the disease
mechanism hinders the development of efficacious therapeutic approaches. The loss of synapses in …

… Synapse damage and loss are fundamental to the pathophysiology of Alzheimer’s disease
(… approaches for AD therapeutics that can demonstrate reduction of synapse damage or loss. …

… of the mechanisms that link Aß and tau to synaptic and cognitive dysfunction, as well as the
… to synaptic deficits and/or loss and how therapeutic approaches focusing on the synapse …

… The cellular and molecular basis of synaptic transmission, at … in one synapse affecting its
efficiency and local synaptic … neurodegeneration at individual synapses affects the coordination …

… (AD), the most prevalent neurodegenerative disease in the … –induced dysfunction of neuronal
synapses through distinct cell … of disease-modifying strategies targeting synaptic failure for …

… diseases, we do not know when the synaptic loss occurred. Aβ peptides and tau proteins play
normal roles at the synapse, … pre- and post-synaptic elements, leading to synaptic loss and …