… due to the additive or synergistic effects of comorbid disease … to overall cognitive decline and
more specific cognitive and … of definite PART requires the absence of β-amyloid [17, 52, 96]. …

… High cholesterol has been associated with increased production of β-amyloid, and the
presence of the APOE ε4 allele may lead to hypercholesterolemia (39). Furthermore, smoking is …

… NT1 levels are synergistic with β-amyloid burden in predicting future cognitive decline …
potential interactions between β-amyloid burden and NT1 with respect to cognitive decline, we …

… brain reserve develop cognitive impairment or dementia with … , coronary artery disease,
transient ischemic attack, and stroke were … cerebrovascular injury may synergistically interact with …

… Although the joint effect of low physical activity and ApoE4 was determined to be additive …
synergistic, these findings further support the role of exercise in preventing cognitive decline in …

… nondemented ischemic and hemorrhagic stroke patients … months) to assess for synergistic
effects of acute stroke features … Existing data suggest that low plasma β-amyloid ratios (42:40…

… would have a synergistic relationship with brain-… for cognitive impairment or dementia,
including vascular dementia. Inclusion criteria for ADNI-1 included a modified Hachinski ischemic …

… is triggered by dysfunctional β-amyloid precursor protein (APP) … risk factor for cognitive
decline, cognitive impairment, and … , but there are synergistic pathomechanisms between AD …

… cognitive impairment in Alzheimer’s disease (AD). We hypothesized that cerebral ischemia
deteriorates cognitive impairment in … Synergistic effects of ischemia and β-amyloid burden on …

… , and Nrf2 overexpression can assist in reducing cerebral ischemic injury and cognitive
impairment in CCH models. On the other hand, increased ROS generated from activated …