Synergy of Interleukin (IL)-5 and IL-18 in eosinophil mediated pathogenesis of allergic diseases

HK Kandikattu, SU Venkateshaiah, A Mishra - Cytokine & growth factor …, 2019 - Elsevier
Eosinophils are circulating granulocytes that have pleiotropic effects in response to
inflammatory signals in the body. In response to allergens or pathogens, exposure
eosinophils are recruited in various organs that execute pathological immune responses. IL-
5 plays a key role in the differentiation, development, and survival of eosinophils.
Eosinophils are involved in a variety of allergic diseases including asthma, dermatitis and
various gastrointestinal disorders (EGID). IL-5 signal transduction involves JAK-STAT …
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