… via the oxidation and polymerization of aromatic ring compounds. … ) melanin from endogenously
synthesized substrates, C. … neoformans is unable to synthesize melanin pigments from …

… species: Cryptococcus neoformans and Cryptococcus gattii. … Two metabolic pathways can
lead to melanin synthesis in … that ultimately polymerize spontaneously into melanin, which is a …

… (D) Analysis of melanin synthesis in the indicated strains. … caspase-1 through polymerizing
the cytoplasmic NLRP3 … spleens of infected mice than from those of the mice infected with the …

… , decision to publish, or preparation of the manuscript. … for survival in mammalian host such
as capsule, melanin and … Repeated cycles of actin polymerization that form around cryptococci…

… neoformans utilizes the laccase enzyme that catalyses the synthesis of melanin in the
presence of the precursor molecule like L-DOPA. The laccase activity was determined in …

… because of their role in lacquer polymerization.Citation 14 Fairly … AIDS-related fungus
Cryptococcus neoformans are wholly … also contribute to the overall synthesis of fungal pigments in …

… damage and invasive fungal growth (Figures 4C and 4D). In addition, in a nonlethal
model of infection of nonimmunosuppressed mice, Atg5 conditional KO, resulted in defective …

… Furthermore, L-DOPA melanin from Cryptococcus neoformans … occurred in vivo, we infected
mice with P. aeruginosa alone … D, an inhibitor of actin polymerization that effectively blocks …

… fungi such as Cryptococcus neoformans. A biosynthesis pathway for fungal DOPAmelanin
strongly … The latter compounds polymerize to form brown and black pigment eumelanins. This …

… were first described in Cryptococcus neoformans and, since then, … that melanin can be
synthesized inside vesicles [68]. … compounds produced during melanin polymerization [68,69]. …