Ferroptosis is a type of cell death related to cancer; however, the characteristics of
ferroptosis in cancers are still uncertain. Based on the data in The Cancer Genome Atlas, we
found that most ferroptosis regulator genes (FRGs) were differentially expressed in tumors,
somatic copy number alterations (SCNA) and DNA methylation contributed to their aberrant
expression. We established the ferroptosis potential index (FPI) to reveal the functional roles
of ferroptosis and noticed that the FPI was higher in tumors than in normal tissues in most …

Cuproptosis is a novel form of cell death driven by a copper-dependent proteotoxic stress
response whose comprehensive landscape in tumors remains unclear. Here, we
comprehensively characterized cuproptosis-related genes (CRGs) across 33 cancers using
multi-omic data from The Cancer Genome Atlas (TCGA), showing complicated and diverse
results in different cancers. We also explored the relationships between CRGs and cancer
metabolic patterns, pathway activity, and tumor microenvironment (TME), suggesting that …