Background Benefits of phosphate-lowering interventions on clinical outcomes in patients
with CKD are unclear; systematic reviews have predominantly involved patients on dialysis.
This study aimed to summarize evidence from randomized controlled trials (RCTs)
concerning benefits and risks of noncalcium-based phosphate-lowering treatment in
nondialysis CKD. Methods We conducted a systematic review and meta-analyses of RCTs
involving noncalcium-based phosphate-lowering therapy compared with placebo, calcium …