Hepatitis B virus-specific CD4 T cell responses differentiate functional cure from chronic surface antigen+ infection
RC Hoogeveen, S Dijkstra, LM Bartsch… - Journal of …, 2022 - Elsevier
… CD4 and CD8 T cell responses in acute resolving infection compared with … , we observed a
broad pattern of recognition covering all HBV proteins, with single … Hepatitis B virus infection …
broad pattern of recognition covering all HBV proteins, with single … Hepatitis B virus infection …
[HTML][HTML] Mutations in hepatitis D virus allow it to escape detection by CD8+ T cells and evolve at the population level
…, ES Alizei, J Bockmann, JS Zur Wiesch, B Budeus… - Gastroenterology, 2019 - Elsevier
… (HDV) superinfection in patients with hepatitis B virus (HBV) is … by virus-specific CD8 + T
cells or why these cells ultimately … I footprint mutations indicate efficient CD8 + T cell pressure, …
cells or why these cells ultimately … I footprint mutations indicate efficient CD8 + T cell pressure, …
TOX defines the degree of CD8+ T cell dysfunction in distinct phases of chronic HBV infection
…, T Boettler, C Neumann-Haefelin, D Zehn, B Bengsch… - Gut, 2021 - gut.bmj.com
… T cell responses compared with active chronic hepatitis B (CHB… sequence mutations as
described in the online supplemental … in virus-specific CD8+ T cells targeting persisting viruses is …
described in the online supplemental … in virus-specific CD8+ T cells targeting persisting viruses is …
T-cell therapy for chronic viral hepatitis
A Bertoletti, AT Tan, S Koh - Cytotherapy, 2017 - Elsevier
… cure rates, curative therapies for hepatitis B virus (HBV) may only … of virus-specific T cells is
extremely low, and virus-specific T … T cell receptors for treatment of virus-related cancers and …
extremely low, and virus-specific T … T cell receptors for treatment of virus-related cancers and …
Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell susceptibility to functional restoration in vitro
…, L Lad, A Loglio, R Soffredini, M Borghi, T Pollicino… - Gut, 2023 - gut.bmj.com
… a severe impairment of virus-specific CD8 T cell responses. … analysis for the identification
of patient cohorts with different … variable virus we investigated whether mutations within the …
of patient cohorts with different … variable virus we investigated whether mutations within the …
Hepatitis B virus persistence and reactivation
Y Shi, M Zheng - bmj, 2020 - bmj.com
… is recognized as crucial in the control of acute HBV infection. … virus-specific B cells in chronic
hepatitis B infection. J Clin … T cell receptor grafting allows virological control of Hepatitis …
hepatitis B infection. J Clin … T cell receptor grafting allows virological control of Hepatitis …
[HTML][HTML] Unraveling the multifaceted nature of CD8 T cell exhaustion provides the molecular basis for therapeutic T cell reconstitution in chronic hepatitis B and C
… T cells that recognize different HBV antigens [24]. Notably, … in chronic hepatitis C a subset
of virus-specific CD8 T cells … [64,93], including ataxia telangiectasia mutated kinase (ATM), the …
of virus-specific CD8 T cells … [64,93], including ataxia telangiectasia mutated kinase (ATM), the …
Hepatitis D virus-specific CD8+ T cells have a memory-like phenotype associated with viral immune escape in patients with chronic hepatitis D virus infection
… Superinfection of chronic hepatitis B with the hepatitis D virus … /epitope multimers to the
T-cell receptor allows the ex vivo … Here, we propose that viral escape mutations with reduced or …
T-cell receptor allows the ex vivo … Here, we propose that viral escape mutations with reduced or …
Targeting virus-specific CD8+ T cells for treatment of chronic viral hepatitis: from bench to bedside
J Lang-Meli, C Neumann-Haefelin… - Expert Opinion on …, 2024 - Taylor & Francis
… of CD8+ T cells failure in chronic hepatitis B, D, C and E virus … knockdown of the endogenous
T cell receptor, for example, … -specific CD8+ T cell responses selects for mutations in up to …
T cell receptor, for example, … -specific CD8+ T cell responses selects for mutations in up to …
Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection
RC Hoogeveen, MP Robidoux, T Schwarz… - Gut, 2019 - gut.bmj.com
… require identification of the requirements for a successful T cell … of T cell receptor stimulation
due to viral escape mutations. … . Hepatitis B virus-specific T cells associate with viral control …
due to viral escape mutations. … . Hepatitis B virus-specific T cells associate with viral control …