Pathophysiology and mechanisms of acute coronary syndromes: atherothrombosis, immune-inflammation, and beyond

G Cimmino, L Di Serafino, P Cirillo - Expert Review of …, 2022 - Taylor & Francis
acute complications, such as the Acute Coronary Syndromes (ACS), is continuously under
investigation. Immunity … reported that oxLDL may induce T-cell activation in TCR independent …

Indoleamine 2, 3-dioxygenase (IDO) enzyme links innate immunity and altered T-cell differentiation in non-ST segment elevation acute coronary syndrome

C Zara, A Severino, D Flego, A Ruggio… - International Journal of …, 2017 - mdpi.com
… To assess if the altered MDDC maturation and IDO pathway could affect T-cell differentiation…
and IDO-dependent immune-modulation or an intrinsic T-cell abnormality, we stimulated …

Altered maturation status and possible immune exhaustion of CD8 T lymphocytes in the peripheral blood of patients presenting with acute coronary syndromes

DA Zidar, JC Mudd, S Juchnowski… - … , and vascular biology, 2016 - Am Heart Assoc
… by CD8 + T-cell populations, comparing corresponding maturation subsets in patients with
ACS and stable CAD. The production of IL-2 and IFNγ after stimulation via the T-cell receptor (…

Interleukin‐9‐secreting CD4+ T cells regulate CD8+ T cells cytotoxicity in patients with acute coronary syndromes

H Gang, D Peng, Y Hu, S Tang, S Li, Q Huang - Apmis, 2021 - Wiley Online Library
… , suggesting that T-cell immunity may be involved in the mechanisms of coronary instability
(… (14), while Foxo1 is involved in T-cell homeostasis and survival, and is considered as tumor …

Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome

J Bullenkamp, V Mengoni, S Kaur… - Cardiovascular …, 2021 - academic.oup.com
… to the control CD28 + T-cell subset. Notably, we demonstrate that CD28 null T-cell expansion
was … Our work emphasizes the need to investigate inflammation and immune responses in …

Adaptive immunity in acute coronary syndromes: chicken or egg?

P Libby, GK Hansson - European Heart Journal, 2018 - academic.oup.com
… to the stimulation of adaptive immunity. As patients with acute coronary syndromes have higher
… for boosting T cell responses may operate particularly during acute ischaemic episodes. …

Immune Disorder in Atherosclerotic Cardiovascular Disease―Clinical Implications of Using Circulating T-Cell Subsets as Biomarkers―

R Neupane, X Jin, T Sasaki, X Li, T Murohara… - Circulation …, 2019 - jstage.jst.go.jp
… Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome
… Clinical features of acute coronary syndromes in patients with human immunodeficiency …

Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap …

DM Leistner, N Kränkel, D Meteva… - European Heart …, 2020 - academic.oup.com
… The different immune signatures identified in this … + T-cell subpopulations (B) as well as
increased T-cell effector molecules at the culprit site distinguishing acute coronary syndromes

Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome

F Chernomordik, B Cercek, J Zhou, X Zhao… - … in Immunology, 2023 - frontiersin.org
diseases and in acute coronary syndrome (ACS). In this report, we profiled the specific T
cell … (AIM) assay demonstrated differential T cell profiles characterized by the persistence of …

The role of T cells reactive to the cathelicidin antimicrobial peptide LL-37 in acute coronary syndrome and plaque calcification

F Chernomordik, B Cercek, WM Lio… - … in immunology, 2020 - frontiersin.org
… in the mCRAMP T cell recipient mice (… T cell response in PBMCs from patients with ACS
stimulated with LL-37 suggests that LL-37-reactive T cells may be involved in the acute event. …