… subtype (anergy, phenotype skewing), (3) prevention of T-cell … antigen-specific T-cell receptor
(TCR) transgenic mice, both … Thus naïve T cells are excluded from nonlymphoid peripheral …

… after T cell activation, where anergy and exhaustion are two … of activated T cells into
non-lymphoid tissues in mice 38,39,40 . … of antigen expression and tolerization of transgenic …

… In a T cell reconstitution setting, selection on C4/IAb is required to prevent T cell infiltration
of … diverse array of T cells expressing T cell antigen receptors (TCRs) that recognize protein-…

… repertoire, we have generated a TCR transgenic mouse that … network of interaction that
comprises non lymphoid cells (eg, … chance to discover how T cell anergy is controlled through …

… , tolerance can result from clonal deletion or clonal anergy. … in nonlymphoid cells, and B
lymphocytes of these mice also … and clonal deletion as mechanisms leading to T-cell tolerance …

… T cell anergy is an important peripheral tolerance mechanism… TCR transgenic mice, or by
adoptive transfer of TCR transgenic T … to induce anergy and are only short-term anergy models. …

… deletion rather than anergy result upon T cell encounter with … NOD-InsHA transgenic
mice that express the model self-… antigen expression occurs such as for islet-expressed neo-…

… that are recurrently enriched in non-lymphoid organs … cells that display hallmarks of T cell
anergy and can serve as … nT FH cells bypass central tolerance and populate the peripheral …

… T cells and high-affinity transgenic self-specific CD8 T cells. … This induced OTI expansion in
the blood and non-lymphoid … in iFABP-Ova mice with anergic OTI (tolerant OTI versus no OTI) …

… infectious tolerance; therefore, we will collectively term them … and favor tolerance via the
induction of T cell anergy and … Nevertheless, preclinical studies utilizing TCR transgenic mice as …