… morphology of nuclear TDP-43-depleted and TDP-43 inclusion-bearing neurons to determine
whether the reduction of nuclear TDP-43 alone is associated with neuronal degeneration. …

… it binds to TDP-43 or whether this is a retention due to non-tau, non-TDP-43 related
neurodegeneration 19,20 . To further study whether 18 F-Flortaucipir binds to TDP-43 related …

… In addition to several RBPs, TDP-43 has also … of TDP-43, the cellular effects of TDP-43
aggregates and their cytotoxic mechanism(s) remain to be clarified. We hypothesize that TDP-43 …

… frontotemporal dementia (FTD). The pathomechanisms underlying abnormal mislocalisation
and aggregation of TDP-43 … and FTD relates specifically to TDP-43, posing the question as …

… Type A is most often associated with behavioral variant frontotemporal dementia (bvFTD)
or progressive non-fluent aphasia (PNFA), while Type B is associated with bvFTD with or …

… Frontotemporal lobar degeneration with TDP-43 inclusions (… decreased with increasing
TDP-43 inclusion pathology in the … specific for pathological or phosphorylated TDP-43 (pTDP-43) …

… inclusions in a subgroup of frontotemporal lobar degeneration (FTLD) and amyotrophic …
TDP-43 pathology in FTLD and ALS. Our aim was to analyze cerebrospinal fluid (CSF) TDP-43 …

… variant frontotemporal dementia, semantic variant primary progressive aphasia, and nonfluent
variant primary progressive aphasia, with behavioral variant frontotemporal dementia as …

… of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). TDP-43 pathology
… Casein kinase-1δ (CK-1δ) was reported to phosphorylate TDP-43 directly. Previous works …

… TDP-43 aggregates are unknown. Here we used cryo-electron microscopy to determine the
structures of aggregated TDP-43 … 282–360 in the TDP-43 low-complexity domain and adopts …