An update on the formation in tobacco, toxicity and carcinogenicity of Nʹ-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

LA Peterson, SB Stanfill, SS Hecht - Carcinogenesis, 2024 - academic.oup.com
… We update the carcinogenicity data by describing some … that form TSNAs occurring throughout
tobacco production and in … the fact that all cigarette smokers have NNAL in their urine. (S)-…

Biomarkers of exposure in urine of active smokers, non-smokers, and vapers

D Gallart-Mateu, P Dualde, C Coscollà… - Analytical and …, 2023 - Springer
… as carbonyl compounds, tobacco-specific nitrosamines (TSNAs), … excreted in the urine as
mercapturic acid [32, 33]. Thus, … creatinine data which varied from 0.31 to 2.83 g L −1 urine , …

Review of health consequences of electronic cigarettes and the outbreak of electronic cigarette, or vaping, product use-associated lung injury

DJ Cao, K Aldy, S Hsu, M McGetrick, G Verbeck… - Journal of medical …, 2020 - Springer
… While the concentration of TSNAs in e-cigarettes is … with 76% of patients aged < 35 years
old and 15% < 18 years [68]. These … While urine quantitative analysis for THC may indicate the …

Challenges involved in the creation of scientific evidence for tobacco control

HM lal Chawla, M Shahid, AK Narula… - Studies in Natural …, 2024 - Elsevier
TSNAs in smoke and also in raw tobacco makes them culprits for NCDs and cancers (Fig.
11.1). Huge data available on the impact of tobacco smokeurinary excretion of NNAL as NNAL

Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems

MN Kanobe, PR Nelson, BG Brown, P Chen, P Makena… - Toxics, 2023 - mdpi.com
… Further, similar reductions in nicotine exposure, TSNAs, and … in smoking status, we
previously reported that urinary … administered through an internal Data Sharing Committee on …

DNA damage, DNA repair and carcinogenicity: Tobacco smoke versus electronic cigarette aerosol

M Tang, HW Lee, M Weng, HT Wang, Y Hu… - … Research/Reviews in …, 2022 - Elsevier
… , do not contain tobacco specific nitrosamines (TSNAs), and … heavy smokers is in stark contrast
to many occupational exposure … Nevertheless, with greatly improved data analysis ability, …

Betel quid containing safrole enhances metabolic activation of tobacco specific 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

HH Tsou, HT Ko, CT Chen, TW Wang, CH Lee… - Environmental …, 2019 - Elsevier
… disease, dietary history and general demographic data. The … Furthermore, NNAL/Cre was
excreted completely within 72 h … for the decreased urinary NNAL and NNAL-Glu observed in …

[PDF][PDF] Biomarkers of exposure to new and emerging tobacco delivery products

SS Hecht, JC Gomez, JR Martin, C Mesaros… - researchgate.net
… ) and TSNA metabolites (eg, NNAL), are specific to the use of … most stable and abundant
TSNA metabolite in urine samples, … Expanded biomar er testing will also expand exposure data

Assessment of the exposure to aromatic amines in users of various tobacco/nicotine products

G Scherer, K Riedel, N Pluym, M Scherer - ACS omega, 2022 - ACS Publications
… the exposure to o-Tol, 2-AN, 3-ABP, and 4-ABP by urinarycigarettes (CCs), electronic
cigarettes (ECs), heated tobaccodata are compatible with our observation that excretion of 2-…

Research progress of N-nitrosamine detection methods: a review

Y Liu, X Guo, Z Wang, Q Zhang, Q Ma, Q Lv - Bioanalysis, 2022 - Future Science
… is excreted intact with urine. Nitrosamine detection in human … Some studies on TSNAs
require urine pH adjustment to … It can collect accurate mass data of materials for analysis to …