Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease

M Chioua, E Buzzi, I Moraleda, I Iriepa, M Maj… - European Journal of …, 2018 - Elsevier
… current interest in the so-called Multitarget Directed Ligands (MTDLs), an heterogeneous …
of MTDLs that we called tacripyrines (I, Fig. 1) by juxtaposition of tacrine and nimodipine, as …

Tacrine hybrids as multi-target-directed ligands in Alzheimer's disease: Influence of chemical structures on biological activities

M Girek, P Szymański - Chemical Papers, 2019 - Springer
ligands, tacrine is bound to numerous moieties with various applications. The hybrids can be
obtained in three ways: first… novel hybrids based on THA and nimodipine called tacripyrines

Tacrines as therapeutic agents for Alzheimer's disease. IV. The tacripyrines and related annulated tacrines

M Bartolini, J Marco‐Contelles - The Chemical Record, 2019 - Wiley Online Library
… of the benzene ring by a 1,4-dihydropyridine, a 1,2,3,4-… of the so called multitarget directed
ligand (MTDL) strategy29,… To get tacripyrine hybrids the benzene ring A of the tacrine

Multitarget tacrine hybrids with neuroprotective properties to confront Alzheimer's disease

K Spilovska, J Korabecny… - Current Topics in …, 2017 - ingentaconnect.com
… -directed ligands (MTDLs) … ,4-dihydropyridine (DHP) nimodipine [106] was chosen as a
Ca2+ antagonist to be connected to THA leading to discovery of novel hybrids called tacripyrines. …

Tacrine-based hybrids: past, present, and future

A Bubley, A Erofeev, P Gorelkin… - International Journal of …, 2023 - mdpi.com
… with natural products (Section 7) and organic ligands (Section 8)… the most potent hybrid
HA’(10)–THA 476, first described by … Most of the tacripyrines were more potent inhibitors of AChE …

[PDF][PDF] Multi-target-directed ligands for AD treatment: inhibitory potency evaluation of donepezil-lipoic acid hybrids

BS Terra, A Tramarin, FM Junior… - Development of … - amsdottorato.unibo.it
… current interest in the so-called Multitarget Directed Ligands (MTDLs), a heterogeneous class
… mode of new hybrid inhibitors, ie donepezil and tacrine hybrids, designed on the basis of …

Rational design of multitarget-directed ligands: strategies and emerging paradigms

J Zhou, X Jiang, S He, H Jiang, F Feng… - Journal of medicinal …, 2019 - ACS Publications
… active ligands together usually resulted in very large molecular weight (MW). (7) For example,
many research studies have published about hybrids of tacrine and other active ligands, …

Recent highlights on molecular hybrids potentially useful in central nervous system disorders

M Matias, S Silvestre, A Falcao… - Mini Reviews in …, 2017 - ingentaconnect.com
Tacripyrines are another relevant class of hybrid structures, which were synthesized from
tacrine … The last compound is a drug composed by a 1,4-dihydropyridine moiety that selectively …

Multi-Target Hybrid Drugs: A Promising Approach for Treating Alzheimer's, Neurological Diseases, Diabetes, and Cancer

A Rezagholi Lalani, F Ebrahimbabaie… - Journal of Chemical …, 2023 - journals.iau.ir
… This review aims to assess the efficacy of acridine- and tacrine-based multi-target hybrid
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the …

Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)

P Mishra, A Kumar, G Panda - Bioorganic & Medicinal Chemistry, 2019 - Elsevier
… and tacrine as potential multitarget-directed ligands for the … new series of tacrine-1,4-dihydropyridine
(tacripyrimedones) … ring with DHP-ring of tacripyrines with general structure of 11-…