… current interest in the so-called Multitarget Directed Ligands (MTDLs), an heterogeneous …
of MTDLs that we called tacripyrines (I, Fig. 1) by juxtaposition of tacrine and nimodipine, as …

… ligands, tacrine is bound to numerous moieties with various applications. The hybrids can be
obtained in three ways: first… novel hybrids based on THA and nimodipine called tacripyrines …

… of the benzene ring by a 1,4-dihydropyridine, a 1,2,3,4-… of the so called multitarget directed
ligand (MTDL) strategy29,… To get tacripyrine hybrids the benzene ring A of the tacrine …

… -directed ligands (MTDLs) … ,4-dihydropyridine (DHP) nimodipine [106] was chosen as a
Ca2+ antagonist to be connected to THA leading to discovery of novel hybrids called tacripyrines. …

… with natural products (Section 7) and organic ligands (Section 8)… the most potent hybrid
HA’(10)–THA 476, first described by … Most of the tacripyrines were more potent inhibitors of AChE …

… current interest in the so-called Multitarget Directed Ligands (MTDLs), a heterogeneous class
… mode of new hybrid inhibitors, ie donepezil and tacrine hybrids, designed on the basis of …

… active ligands together usually resulted in very large molecular weight (MW). (7) For example,
many research studies have published about hybrids of tacrine and other active ligands, …

… Tacripyrines are another relevant class of hybrid structures, which were synthesized from
tacrine … The last compound is a drug composed by a 1,4-dihydropyridine moiety that selectively …

… This review aims to assess the efficacy of acridine- and tacrine-based multi-target hybrid …
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the …

… and tacrine as potential multitarget-directed ligands for the … new series of tacrine-1,4-dihydropyridine
(tacripyrimedones) … ring with DHP-ring of tacripyrines with general structure of 11-…