… NK cells directly kill target tumor cells through the apoptosis mechanism by releasing
cytoplasmic granules containing perforin and granzymes, or by expressing death receptor ligands …

… To prevent potential loss of DCs during culture of the Tax-transduced peripheral blood
mononuclear cells (… We next selected lung cancer cells as model target cells. Three lung cancer …

… Cytotoxic cells kill their targets via two major pathways: perforin/granzyme–… peripheral
blood and the lung.1, 14 Comparative studies have shown that human CD56 dim NK cells …

… Nevertheless, there is not much information on its effects on normal cells and the … study
aimed to investigate the cyto/genotoxic activity of MEL in human peripheral blood lymphocytes (…

… mutually interact with allogeneic natural killer cells. In this … the EBV + target B cells used
for the cytotoxicity assay. These … (30 Gy) peripheral blood mononuclear cells or allogeneic-…

… Target cells were stained with 5 µg/mL of Calcein AM (Thermo Fisher) for 15 … target
cells in 10 µL were incubated with effector cells (CAR-transduced or control cytotoxic T-lymphocytes) …

… Our genotoxicity assessment in lymphocyte model was focused on three comet parameters:
tail length, tail intensity, and total area, all of which were simultaneously measured by the …

… have been detected at low frequencies in the peripheral blood (PB) of healthy donors but
are found at significantly higher frequencies in myeloid leukemia patients where their …

… immunotherapy, we explored whether lymphocytes that target tumor-specific neoantigens
frequently occur in peripheral blood and could thus be more easily exploited therapeutically. …

… cytotoxicity and CD3 + CD57 + T cell characteristics. Peripheral blood lymphocytes and
P815 target cells with added anti-CD3 were co-cultured for 4 h, and target cell cytotoxicity was …