IFNγ enhances cytotoxic efficiency of the cytotoxic T lymphocytes against human glioma cells

S Shao, E Risch, D Burner, L Lu, B Minev… - International …, 2017 - Elsevier
… imDCs were generated from HLA-A2 positive peripheral blood mononuclear cells (PBMC) …
cytokine targets the human glioma cells to the CTLs we generated with the modified human

Natural killer cells in cancer immunotherapy

JS Miller, LL Lanier - Annual review of cancer biology, 2019 - annualreviews.org
… on NK cells and T cells provide attractive targets for the … natural killer-resistant fresh
solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes

Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells

AY Jong, CH Wu, J Li, J Sun, M Fabbri… - Journal of …, 2017 - Taylor & Francis
… are activated in target cells after incubation with aNK cell-derived EVs… Peripheral blood
mononuclear cells (PBMC) were isolated by … human cytotoxic T lymphocytes and NK cells secrete …

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69− CD56dim cells

N Marquardt, E Kekäläinen, P Chen… - Journal of allergy and …, 2017 - Elsevier
… resident lymphocytes, including T cells and NK cells,… target cells compared with NK cells in
peripheral blood (Fig 2, C), indicating that the former were impaired both in natural cytotoxicity

In vitro safety assessment of the strawberry tree (Arbutus unedo L.) water leaf extract and arbutin in human peripheral blood lymphocytes

K Jurica, I Brčić Karačonji, A Mikolić… - Cytotechnology, 2018 - Springer
… Studies focused on in vitro genotoxicity of other polyphenol constituents present in A. unedo
… To establish the levels of DNA damage in treated lymphocytes, we focused on two comet …

Natural killer cells and other innate lymphoid cells in cancer

L Chiossone, PY Dumas, M Vienne… - Nature Reviews …, 2018 - nature.com
… studies have shown peripheral blood natural cytotoxicity to be … that aimed to restore
intratumoural NK cell-mediated cytotoxicity … It should be noted that the lack of tumour lymphocyte

Investigation of genetic toxicity and oxidative stress of Clostridium perfringens epsilon toxin type D on human peripheral blood lymphocytes

M Shokrzadeh, A Zeyar, R Golmohammadi… - Microbial …, 2021 - Elsevier
target tissues and cells of the host organism, pathogenic bacteria behave differently. Between
them, toxin production creates an efficient way to modify specific functions of target cells. …

[HTML][HTML] The role of natural killer cells in hepatocellular carcinoma development and treatment: A narrative review

S Juengpanich, L Shi, Y Iranmanesh, J Chen… - Translational …, 2019 - Elsevier
… studies have shown that targeting Natural Killer cells, as major … Peripheral blood Natural
Killer cells can be expanded and … of cytotoxicity of Natural killer cells and CD8 + T lymphocytes

iPSC-derived natural killer cell therapies-expansion and targeting

BH Goldenson, P Hor, DS Kaufman - Frontiers in immunology, 2022 - frontiersin.org
… sources each possess advantages and disadvantages for use in cellular therapy targeting
cancer (30). Peripheral blood NK (PB-NK) cells must be collected from a donor by apheresis …

Natural killer cell immunotherapies against cancer: checkpoint inhibitors and more

L Chiossone, M Vienne, YM Kerdiles, E Vivier - Seminars in immunology, 2017 - Elsevier
… drug targeting in vivo include natural killer (NK) cells. These … of total peripheral blood
mononuclear cells (PBMCs) in humans … ) are also expressed by cytotoxic T lymphocytes, and mAb …