Targeting natural killer cells in solid tumors

G Habif, A Crinier, P André, E Vivier… - Cellular & molecular …, 2019 - nature.com
… In human peripheral blood, NK cells are defined as CD14 − CD19 − CD3 − and can be … 1
(KLRG1), cytotoxic T lymphocyte antigen 4 (CTLA4) and lymphocyte activation gene 3 protein (…

[HTML][HTML] Human peripheral blood eosinophils express high levels of the purinergic receptor P2X4

V Paalme, A Rump, K Mädo, M Teras… - Frontiers in …, 2019 - frontiersin.org
… assays, indicating that they target conformational epitopes. We … human peripheral blood
lymphocytes (PBL). We showed that P2X4 is expressed at the surface of several leukocyte cell

[HTML][HTML] The safety and anti-tumor effect of multiple peptides-pulsed dendritic cells combined with induced specific cytotoxic T lymphocytes for patients with solid …

X Zhao, Z Zhang, C Wen, J Huang, S Yang… - Frontiers in …, 2023 - frontiersin.org
… peptides for each patient through the multi-target prediction of antigens, which may offer …
targeted therapy for solid tumors by infusing immune cells (18). Herein, the peripheral blood

[HTML][HTML] Natural killer cells for immunotherapy–advantages of the NK-92 cell line over blood NK cells

H Klingemann, L Boissel, F Toneguzzo - Frontiers in immunology, 2016 - frontiersin.org
… obtained from the peripheral blood of either the patient (… 10% of circulating blood lymphocytes
are NK cells: to collect … CXCR2 is responsible for targeting cytotoxic cells to solid tumors (…

[HTML][HTML] Human double negative T cells target lung cancer via ligand-dependent mechanisms that can be enhanced by IL-15

J Yao, D Ly, D Dervovic, L Fang, JB Lee… - … for ImmunoTherapy of …, 2019 - Springer
… Double negative T cells (DNTs) comprise 3–5% of the peripheral blood mature T lymphocyte
… Given the similarity in cytotoxic cell surface marker expression between TCRαβ and TCRγδ …

[HTML][HTML] Brain ischemia significantly alters microRNA expression in human peripheral blood natural killer cells

Y Kong, S Li, X Cheng, H Ren, B Zhang, H Ma… - Frontiers in …, 2020 - frontiersin.org
… miRNAs that were altered after acute ischemic stroke, many are predicted to regulate a
number of target genes and pathways associated with lymphocyte activation, mobilization, and …

Targeted natural killer cell–based adoptive immunotherapy for the treatment of patients with NSCLC after radiochemotherapy: a randomized phase II clinical trial

G Multhoff, S Seier, S Stangl, W Sievert… - Clinical Cancer …, 2020 - AACR
… activated mHsp70-targeting NK cells in the peripheral blood, and elevated … Peripheral blood
lymphocytes (PBL) were isolated by density gradient centrifugation in a closed SEPAX Cell

In vitro genotoxic and cytotoxic effects of some paraben esters on human peripheral lymphocytes

D Güzel Bayülken, B Ayaz Tüylü - Drug and Chemical Toxicology, 2019 - Taylor & Francis
… in this study have highly genotoxic and cytotoxic effects on human lymphocytes cells in vitro.
… An increased MN frequency in peripheral blood lymphocytes may be indicate cancer risk in …

[HTML][HTML] 'Off-the-shelf'immunotherapy with iPSC-derived rejuvenated cytotoxic T lymphocytes

M Ando, H Nakauchi - Experimental hematology, 2017 - Elsevier
… Adoptive T-cell therapy to target and kill tumor cellsperipheral blood T lymphocytes were
transduced with a lentiviral vector encoding a particular CAR, followed by induction of T-cell

[HTML][HTML] Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

T Maehara, N Kaneko, CA Perugino… - The Journal of …, 2020 - Am Soc Clin Investig
… contribution of infiltrating B cells to pathology in SSc, we focused on the T cells in the infiltrate
across … compared with all other cytotoxic cell types, such as γδ T cells, CD8 + CTLs, and NK …