Targeted hypoglossal nerve stimulation for patients with obstructive sleep apnea: a randomized clinical trial

AR Schwartz, O Jacobowitz, DW Eisele… - … –Head & Neck …, 2023 - jamanetwork.com
Importance Evidence is lacking from randomized clinical trials of hypoglossal nerve
stimulation in obstructive sleep apnea (OSA). Objective To evaluate the safety and
effectiveness of targeted hypoglossal nerve stimulation (THN) of the proximal hypoglossal
nerve in patients with OSA. Design, Setting, and Participants This randomized clinical trial
(THN3) was conducted at 20 centers and included 138 patients with moderate to severe
OSA with an apnea-hypopnea index (AHI) of 20 to 65 events per hour and body mass index …
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