Dry powder aerosol containing muco-inert particles for excipient enhanced growth pulmonary drug delivery

G Chai, A Hassan, T Meng, L Lou, J Ma… - … , Biology and Medicine, 2020 - Elsevier
… We conducted a proof-of-concept study usingusing an excipient enhanced growth (EEG)
strategy, aiming to minimize extrathoracic airway loss, maximize deposition in the airway and …

Excipient Enhanced Growth Aerosol Surfactant Replacement Therapy in an In Vivo Rat Lung Injury Model

FJ Kamga Gninzeko, MS Valentine, CK Tho… - … and Pulmonary Drug …, 2020 - liebertpub.com
target the small airways. We have developed an excipient enhanced growth (EEG) powder
aerosol formulation … helps target the site of deposition and prevents exhalation of the …

Challenges and successes using nanomedicines for aerosol delivery to the airways

P Resnier, A Mottais, Y Sibiril, T Le Gall… - Current gene …, 2016 - ingentaconnect.com
… To conclude, the localization of aerosol deposition depends … mucus and then penetrate
into targeted cells (cancerous or … -drying insulin with excipients including mannitol or glycine. …

[HTML][HTML] Dual targeting powder formulation of antiviral agent for customizable nasal and lung deposition profile through single intranasal administration

HC Seow, Q Liao, ATY Lau, SWS Leung, S Yuan… - International Journal of …, 2022 - Elsevier
… was used as the sole excipient to enhance drug solubility. With the … and lower airways for
the prevention and treatment of human … desirable aerosol deposition profile at the target sites. …

Regional deposition: targeting

AR Martin - Journal of aerosol medicine and pulmonary drug …, 2021 - liebertpub.com
… The aim is straightforward: to increase the therapeutic effect of the drug at its targeted … is
the predominant mechanism of aerosol deposition in the upper and central airways; therefore, …

Respiratory tract: structure and attractions for drug delivery using dry powder inhalers

NA ElKasabgy, IM Adel, MF Elmeligy - AAPS PharmSciTech, 2020 - Springer
Respiratory tract can be divided into upper airways, central … ,14,15): (a) a more targeted drug
delivery to the lungs in high … drug with or without other excipients for example together with …

Excipients for Novel Inhaled Dosage Forms: An Overview

C Yousry, M Goyal, V Gupta - AAPS PharmSciTech, 2024 - Springer
… mouth, and following drug deposition in lung airways, has … enhance its absorption or deposition
in the target lung regions, … concentration to produce homogeneous aerosol droplets [46]. …

[HTML][HTML] Aerosol pulmonary immune engineering

ER Sudduth, M Trautmann-Rodriguez, N Gill… - Advanced Drug Delivery …, 2023 - Elsevier
… of complexing these materials into drug delivery vehicles for enhanced release outcomes. …
key immune targets, fundamentals of aerosol drug delivery, and preclinical pulmonary models …

Rational particle design to overcome pulmonary barriers for obstructive lung diseases therapy

Y He, Y Liang, R Han, WL Lu, JCW Mak… - Journal of Controlled …, 2019 - Elsevier
lung barriers based on excipients selection, particle size and surface properties, release
properties and targeting … the lung, including mucus and preciliary barriers and airway epithelial …

Patented therapeutic drug delivery strategies for targeting pulmonary diseases

AK Thakur, DK Chellappan, K Dua… - Expert opinion on …, 2020 - Taylor & Francis
target sites may get deposited in the numerous airway … may grow in size as they pass
through the humid airway, … The use of aerosol inhalers for respiratory conditions dates back to …