… , targeting the glucose metabolism of tumor cells is a potential therapeutic approach for
improving the efficacy of radiation therapy. … PI3K/AKT/mTOR and HIF-1 pathways influence SCLC …

… responses to hypoxia. In addition, we outline emerging hypoxia- targeting strategies that
hold promise for individualized cancer therapy in the context of radiotherapy and drug delivery. …

… to improve tumor control. In summary, there are opportunities to enhance the efficacy of
radiotherapy … -inherent vulnerabilities and dynamic microenvironmental components of the tumor. …

… radiotherapy as an approach to abolish tumor hypoxia and eradicate both GSCs and glioma
differentiated cells, and therefore offer an approach to improve radiotherapy efficacy. … HIF-1 …

… the HIF-1 target gene CAIX verified the knockdown of HIF-1 … improve the effectiveness of
radiotherapy. The approach used in this study was to induce transient hypoxic stress in tumors …

… (DDR), vasculogenesis and glucose metabolism reprograming, … Targeting HIF-1 and its
signal pathways is a promising … the efficacy and precision of radiotherapy for cancer treatment, …

… for hypoxia-targeting… hypoxia for radiotherapy optimization, and we highlight novel insights
into the molecular pathways involved in hypoxia that might be utilized to increase the efficacy …

… considerable potential to improve treatment efficacy, ameliorate … 1α-induced glucose metabolic
reprogramming contributes to … highlights that targeting HIF-1 in cancer and cancer stem …

… Activation of the PI3K/Akt pathway upregulates the efficiency of the translation initiation of …
as HIF-1, could be exploited as rational targets for enhancing the effects of radiotherapy and …

… The T-cells infiltrated into the tumors identify the target tumor cells expressing MHC-1
and kill them through two pathways. First, the cytotoxic T-cells injure the membrane of …