Understanding mechanisms of drug resistance in epilepsy and strategies for overcoming it

K Łukawski, SJ Czuczwar - Expert opinion on drug metabolism & …, 2021 - Taylor & Francis
… ) is a new treatment strategy for severe pediatric epilepsies [… possibility of treatment targeting
a specific etiology of epilepsy [… Table 1 shows treatment strategies for drug-resistant epilepsy

Mechanisms of drug resistance in the pathogenesis of epilepsy: role of neuroinflammation. A literature review

ED Bazhanova, AA Kozlov, AV Litovchenko - Brain Sciences, 2021 - mdpi.com
inflammatory and other components of epileptogenesis can contribute to the further development
of the therapeutic treatment of drug-resistant epilepsy… autoantibodies targeting synaptic …

Targeting inflammatory mediators in epilepsy: a systematic review of its molecular basis and clinical applications

G Costagliola, G Depietri, A Michev, A Riva… - Frontiers in …, 2022 - frontiersin.org
… the therapeutic strategy against drug-resistant epilepsy and RSE, there is increasing interest
in the role of agents targeting … with epilepsy was conducted in May 2021 and updated in …

Targeting neuroinflammation via purinergic P2 receptors for disease modification in drug-refractory epilepsy

T Engel, J Smith, M Alves - Journal of Inflammation Research, 2021 - Taylor & Francis
… Citation13 With the majority of ASDs targetingtreatment strategies targeting underlying
causes that provide long-lasting seizure control, either preventing the development of epilepsy or …

Drug resistance in epilepsy: clinical impact, potential mechanisms, and new innovative treatment options

W Löscher, H Potschka, SM Sisodiya, A Vezzani - Pharmacological reviews, 2020 - ASPET
… The more complex experimental models of drug-resistant seizures discussed in … therapeutic
failure but also for the selection of novel drug candidates targeting difficult-to-treat epilepsy

Drug-resistant epilepsy—time to target mechanisms

H Lerche - Nature Reviews Neurology, 2020 - nature.com
… of therapeutic strategies that prevent and reverse epileptogenesis. … drug-resistant epilepsy
Despite this shift, a clear picture of the disease mechanisms leading to drug-resistant epilepsy

On the Development of New Drugs for the Treatment of Drug-Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses

A Talevi - … : From Genes and Molecules to Promising Therapies, 2023 - Springer
… This chapter, which intends to be a critical update of the one … refractory epilepsy as well as
plausible therapeutic strategies … brain could be enhanced by passive targeting of the seizure-…

Clinical management of drug resistant epilepsy: a review on current strategies

D Guery, S Rheims - Neuropsychiatric Disease and Treatment, 2021 - Taylor & Francis
… While remission was observed whatever the treatment strategy in 72% of patients in one …
that some molecules might be used to target epilepsy-related pathological process that might …

Drug resistance in epilepsy

E Perucca, P Perucca, HS White, EC Wirrell - The Lancet Neurology, 2023 - thelancet.com
… to a comprehensive epilepsy centre for diagnostic re-evaluation and targeted … of drug-resistant
epilepsy and its mechanisms and developing strategies by which drug-resistant epilepsy

Emerging molecular targets for anti-epileptogenic and epilepsy modifying drugs

K Łukasiuk, W Lasoń - International Journal of Molecular Sciences, 2023 - mdpi.com
… of seizures may be targeted by antiepileptogenic therapy … This makes it difficult to think about
designing a treatment strategy … -responsive and drug-resistant epilepsy has been observed …