… induces TEAD4 nuclear translocation to OXPHOS promoter region … , which has a high pyruvate
kinase activity and is abundantly … Moreover, metformin affects not only OXPHOS but also …

… disease that affects one in … in prostate cancer (PCa) cells, which leads to metabolic inactivation
through oxidation and Src-mediated phosphorylation, resulting in nuclear translocation of …

… of metabolic enzymes, like pyruvate kinase M2 (PKM2) that … that macrophages may supply
OXPHOS-impaired tumours by … -reprogrammed (not mitochondria-defective) prostate cancer …

… cells to OXPHOS is sustained by the nuclear translocation of pyruvate kinase isoform M2 (…
We confirmed that CAF-CM impaired SDH expression and activity in PCa cells and leads to …

… cells, suggesting that impairing such metabolic reprogramming … -58, a molecule that induces
pyruvate kinase M2 (PKM2) … for using OXPHOS inhibitors to target metabolic reprogramming …

… ) signaling affects the phenotype of prostate epithelial cells at … infiltrated cancers is the
pyruvate kinase PKM2 isoform, the … Accordingly, targeting PKM2 nuclear translocation by DASA-…

… ), is driven by pyruvate kinase M2 nuclear localization, functional association with HIF-…
Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate …

… observed to suppresses melanoma and prostate metastasis by a different … reprogramming
of cancer cells, impairing cell growth and invasion [112,… PKM2 Pyruvate kinase M2 isoenzyme …

… Pyruvate kinase isozyme 2 (PKM2) has been shown to be … On the other hand, impaired
mitochondrial OXPHOS and … of the AKT3 kinase that, in turn, triggers the nuclear localization of …

… thereby driving the stromal-induced EMT in prostate cancer cells… offer an array of potential
targets to impair the EMT process. … Finally, the pyruvate kinase (PK) enzyme has been recently …