[图书][B] The Many Functions of STN1 in Telomere Regulation and DNA Replication

CP Caridi - 2016 - search.proquest.com
… in vitro and also associates with both telomeric and … destabilize g-quartets in conjunction
with telomerase-mediated … the primase and polymerase activities of DNA pol α/primase and …

Unravelling the Intricacies of Telomere Replication: A Molecular Conundrum

N Datta - Canadian Journal for the Academic Mind, 2024 - cjam.journals.yorku.ca
RNA that adapts to the diverse requirements of telomere … and assist in recruiting DNA
polymerase αprimase for the synthesis … G4 in vitro and coimmunoprecipitates with TRF1–TRF242. …

Sequential phosphorylation of CST subunits by different cyclin-Cdk1 complexes orchestrate telomere replication

V Gopalakrishnan, CR Tan, S Li - Cell Cycle, 2017 - Taylor & Francis
… the recruitment of Cdc13 to telomeres in yeast strains lacking … in vitro, it is likely antagonized
by phosphatase in vivo which … , our results from in vivo and in vitro experiments suggest that …

POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies

E Nicolas, EA Golemis, S Arora - Gene, 2016 - Elsevier
… Polα functions as a DNA primase, while Polε synthesizes the … of Okazaki fragments requires
the attachment of RNA primers … telomerase, which catalyzes addition of telomeric TG-rich …

Roles for the 8-oxoguanine DNA repair system in protecting telomeres from oxidative stress

M De Rosa, SA Johnson, PL Opresko - Frontiers in cell and …, 2021 - frontiersin.org
… length homeostasis and integrity, and underscores the need … guanine lesions in telomeres
in vivo, and that low basal telomeric 8-… telomere replication and telomerase mediated telomere

Repositioning the Sm-Binding Site in Saccharomyces cerevisiae Telomerase RNA Reveals RNP Organizational Flexibility and Sm-Directed 3′-End Formation

EP Hass, DC Zappulla - Non-coding RNA, 2020 - mdpi.com
RNA contains a template for synthesizing telomeric DNA and … to form the holoenzyme but
does not need to hold them in a … permuting the telomerase RNA transcript in vivo, despite the …

Telomeres and telomerase in basal Metazoa

…, V Russo, T Persichini, M Colasanti, A Sgura - Invertebrate Survival …, 2017 - isj.unimore.it
… is required to maintain chromosome physiology, and loss of telomeric DNA or mutations of
telomere-… Targeting telomerase and telomeres to enhance ionizing radiation effects in in vitro

RPA-like single-stranded DNA-binding protein complexes including CST serve as specialized processivity factors for polymerases

AT Barbour, DS Wuttke - Current Opinion in Structural Biology, 2023 - Elsevier
… and other single-stranded regions of the genome require … the switch from polymerase-α-primase
to polymerase-δ on the … of telomerase-mediated extension of a telomeric primer with …

Tel1/ATM signaling to the checkpoint contributes to replicative senescence in the absence of telomerase

L Menin, CV Colombo, G Maestrini, MP Longhese… - Genetics, 2019 - academic.oup.com
Telomeres progressively shorten at every round of DNA replication in the absence of … the
threshold of telomeric signals required for checkpoint activation in the absence of telomerase. …

Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance

SY Mersaoui, RJ Wellinger - Current genetics, 2019 - Springer
… of the telomeric repeat DNA present and this DNA is required for … telomere capping and
telomerase-mediated telomere … Via functional analyses in vivo that were combined with co-…