Spinal α2‐adrenoceptors and neuropathic pain modulation; therapeutic target
Z Bahari, GH Meftahi - British Journal of Pharmacology, 2019 - Wiley Online Library
… mediated spinal nociceptive synaptic transmission along with the maintenance phase of LTP
of C-fibre-evoked … the α 2 -adrenoceptor receptor as a target for the treatment of neuropathic …
of C-fibre-evoked … the α 2 -adrenoceptor receptor as a target for the treatment of neuropathic …
The differential in vivo contribution of spinal α2A- and α2C-adrenoceptors in tonic and acute evoked nociception in the rat
G López-Córdoba, G Martínez-Lorenzana… - Frontiers in …, 2022 - frontiersin.org
… on spinal analgesia supports the relevance of α 2A and … is mediated by α 2A - but not α
2B/2C -adrenoceptor activation. … type of adrenergic receptor stimulated, the localization of the …
2B/2C -adrenoceptor activation. … type of adrenergic receptor stimulated, the localization of the …
Sustained suppression of hyperalgesia during latent sensitization by μ-, δ-, and κ-opioid receptors and α2A adrenergic receptors: role of constitutive activity
WM Walwyn, W Chen, H Kim, A Minasyan… - Journal of …, 2016 - Soc Neuroscience
… represents an opioid receptor-mediated suppression of a … is a sustained state of pain
hypersensitivity that is continuously … were used to measure Cav currents evoked by a two-pulse …
hypersensitivity that is continuously … were used to measure Cav currents evoked by a two-pulse …
α2 adrenoceptor: A target for neuropathic pain treatment
L Di Cesare Mannelli, L Micheli… - Mini reviews in …, 2017 - ingentaconnect.com
… NE effects are mediated by adrenergic receptors (ARs) … On the contrary, the three α2 AR
subtypes (α2A, α2B and α2C) … Under normal conditions, noxious stimulation evoked an early LC …
subtypes (α2A, α2B and α2C) … Under normal conditions, noxious stimulation evoked an early LC …
[HTML][HTML] Antinociception induced by a novel α2A adrenergic receptor agonist in rodents acute and chronic pain models
RT Sudo, RV do Amaral, CE da Silva Monteiro… - European Journal of …, 2017 - Elsevier
… Given that the α 2 -adrenoceptor-mediated alleviation of hypersensitivity after peripheral
nerve inflammation is associated with a reduction of pro-inflammatory cytokines in peripheral …
nerve inflammation is associated with a reduction of pro-inflammatory cytokines in peripheral …
… μ-opioid receptor in the rat spinal cord contributes to the α2-adrenoceptor agonist dexmedetomidine-induced attenuation of chronic morphine tolerance in cancer pain
P Zhang, J Bu, X Wu, L Deng, M Chi, C Ma… - Journal of Pain …, 2020 - Taylor & Francis
… Opioid receptor internalization and desensitization mediated … Opioid and adrenergic receptors
both belong to the family of … DEX relieved the cancer-evoked pain in the state of morphine …
both belong to the family of … DEX relieved the cancer-evoked pain in the state of morphine …
Dexmedetomidine modulates transient receptor potential vanilloid subtype 1
… 2 adrenergic receptor agonist and novel sedative drug with minimal respiratory suppression,
have shown anti-nociceptive activity in various pain … -mediated analgesic effect [12]. It would …
have shown anti-nociceptive activity in various pain … -mediated analgesic effect [12]. It would …
Cingulate alpha-2A adrenoceptors mediate the effects of clonidine on spontaneous pain induced by peripheral nerve injury
YJ Wang, ZX Zuo, C Wu, L Liu, ZH Feng… - Frontiers in molecular …, 2017 - frontiersin.org
… agonist of α 2 adrenoceptors, showed significant analgesic … α 2A adrenoceptors in the
regulation of both evoked pain and … As different subtypes of α 2 adrenoceptors are expressed in …
regulation of both evoked pain and … As different subtypes of α 2 adrenoceptors are expressed in …
Dexmedetomidine Inhibits ASIC Activity via Activation of α2A Adrenergic Receptors in Rat Dorsal Root Ganglion Neurons
S Wei, CY Qiu, Y Jin, TT Liu, WP Hu - Frontiers in Pharmacology, 2021 - frontiersin.org
… DEX suppressed ASIC-mediated and acid-evoked currents and … α2-ARs mediate DEX-induced
inhibition of ASIC currents in … of ASIC-mediated the electrophysiological activity and pain, …
inhibition of ASIC currents in … of ASIC-mediated the electrophysiological activity and pain, …
8 a2 Agonists in the management of acute pain
JA Elliott, HS Smith - Handbook of Acute Pain Management, 2016 - api.taylorfrancis.com
… Many of the clinical analgesic effects of α2 agonists are mediated by … adrenergic receptor
subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal …
subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal …