… RNAPII is distinguished from RNA polymerases I and III by the conserved C-terminal domain
(CTD) of its largest subunit, Rpb1, which plays an integral role in the recruitment of proteins …

… couples Pol II to a suite of factors that regulate transcription … , mRNA processing, chromatin
modification and even DNA … transcript is crucial because downstream mRNA processing, …

RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units – a
reaction always brought to a close by its termination. Because Pol II transcribes multiple gene …

… transcription is directly coupled to mRNA processing, which occurs cotranscriptionally. When
RNA polymerase II (Pol II) … understanding of how RNA Pol II terminates transcription, mainly …

… Pre-mRNA splicing is an essential step for eukaryotic gene expression to remove … Pol II
CTD phosphorylation has been shown to play important roles that smoothly couple transcription …

… to the RNA polymerase II (Pol II) C-terminal domain (CTD) … Pol II pausing, CTD Ser2
phosphorylation, and processing … sites of Pol II pausing and CstF recruitment to the transcription …

… This untethering may be essential to reposition CDK7 for phosphorylation of the C-terminal
domain (CTD) of the Pol II RPB1 subunit. Based on data from yeast PICs, this repositioning of …

… of RNA Pol II and its low complexity C-terminal domain … (D) The role of the CTD in RNA
processing (splicing, capping, … believed to regulate the transcriptional activity of RNA Pol II. …

… The production of mRNA is a dynamic process that is highly regulated by reversible post-translational
modifications of the C-terminal domain (CTD) of RNA polymerase II. The CTD is a …

… of mRNA processing has permitted the evolution of mechanisms that functionally couple
transcription … with an essential appendage, the C-terminal heptad repeat domain (CTD) of the …