… infiltrating immune system, with particular focus on natural killer … Immune checkpoints primarily
regulate T-cell responses, … cells, NK cells and professional antigen-presenting cells (APCs…

… a large number of tumours to evade the immune response.24, … antigen processing, tumours
use the tightly regulated nature … a heterogeneous population of cells including immune cells, …

… natural antibodies, B-1 cells also actively contribute to pathogen-induced immune responses
… may support a certain number of B-1 cells to differentiate to natural antibody-producing cells…

… heterogeneity, possibly by protecting antigenic clones from elimination by the … Regulatory
programs that control the function of stem cells are active in cancer and confer properties that …

… or infections, can induce type 2 immune responses through … this response is differentially
triggered and regulated between … 33 are likely to contribute to the amount of protein released. IL-…

… can be used to deconvolve immune system heterogeneity by … the immune system to
achieve the broad diversity of antigen … types of infection and regulating immunological self-tolerance…

… and reduced sensitivity to vaccine-elicited antibodies 9 , and for which … and quality of immune
responses may be suboptimal. … (quantity) and/or lower-affinity antibodies (quality) resulting …

… -hot or -cold based on whether it favor an effective anti-tumor immune response or not. … ,
indicating an immunological depletion of antigenic subclones [67]. Notably, regulatory T cells (…

… homeostasis and antigen-specific immune response regulation. … Thus, the migration properties
of T-regulatory cells are … Treg pool is a function of the number of effectors capable of IL-2 …

… characteristics coexist within the same tumor.1,2 Tumor … higher fractions of immunosuppressive
regulatory T cells (Tregs; p ≤ … the antibodies against those antigens,3 our result does not …