… -400 nm and can penetrate into the dermis of the skin. UV-B … In addition to these findings,
IGF-1/IGF-1R activity has been … epidermal, and or upper dermal layers of the skin creates raw …

… understanding of aging-associated skin carcinogenesis [7,8]. … The relevance of this signaling
pathway to the suppression of … the IGF-1/IGF-1R system to that found in young skin. Thus, …

… dermal fibroblasts in geriatric skin express lower levels of the hormone insulin-like growth
factor-1 (IGF-1) than young adult skin and that deficient IGF-1 signaling … aging associated with …

… of biglycan and decorin protein are mediated by IGF-1/IGF-1R binding, I treated IGF-1 in …
IGF-1/IGF-1R signaling axis in the skin: a new role for the dermis in agingassociated skin …

… However, as aggrecan is not a major PG in dermal fibroblasts, the role of ADAMTS5 in
skin or dermal fibroblasts have been rarely reported. However, ADAMTS5 is also known to …

… in both human skin ex vivo and … signaling and that this phenotype is correlated with increased
mutagenesis in keratinocytes in vitro. Thus, altered IGF-1/IGF-1R signaling in geriatric skin …

… to the development of aging-associated squamous cell … , the epidermis and superficial
dermis were removed from an … like growth factor receptor I signaling pathway is an essential …

… of IGF-1/IGF-1R signaling causes decreased skin thickness … Also, the expression of IGF-1R
by the dermal papilla appears … development of agingassociated non-melanoma skin cancer…

… Consistent with this hypothesis, the age-dependent accumulation of senescent fibroblasts
in the dermis of the skin may lead to a tumor-promoting environment that influences how …

… Every patient suffering from acromegaly presents soft tissue overgrowth and skin thickening.
Skin puffiness due to dermal glycosaminoglycan accumulation and edema are most …