… KATP channels are involved in amyloid-β (Aβ)-induced … In animal models, subclinical
doses of a KATP blocker tolbutamide or a KATP opener diazoxide differentially restrained Aβ-…

… AβPPxPS1, and 3xTg-AD transgenic mice models, found that … For example, inhibition of
tau kinases and/or activation of … p-tau- PROTACs to reduce p-tau toxicity and improve the …

… We also show that diazoxide (Dz), a K ATP channel agonist … ,17 , improved amyloid pathology
and memory impairment in … an AD mouse model and in postmortem brain of patients with …

… of AD at best only improve them temporarily 13 , and their … developed in appropriate animal
models and clinical settings to … of other strategies, such as diazoxide, melatonin, resveratrol, …

… and histopathology in the 3xTgAD mouse model of AD 8 , … and improved memory deficits
in transgenic prion-disease … Approximately two thirds of all Alzheimer's patients are women. …

… of dendritic spines in a mouse model of AD and inhibit the … -antly prolongs the lifespan of
3xTg AD mice. These findings support … This review provides various strategies that can improve …

… of disease-related self-aggregating proteins such as amyloid β… Diazoxide, an agent that opens
mitochondrial ATP-sensitive … 4 months ameliorated spatial learning and memory deficits in …

… , diazoxide, a K ATP channel activator, reduced tau pathology and improved memory compared
to 3xTg-AD … in APP/PSI mice (in another mouse model of AD) [52]. In the present study, a …

… in Alzheimer's disease brain: central role for amyloid β-… KATP channel activator diazoxide
ameliorates amyloid-beta and tau pathologies and improves memory in the 3xTgAD mouse …

… , subsequently, pathological markers such as amyloid-β (Aβ), tau, and … Meanwhile, K-ATP
channel deficiencies can trigger the … The induction of K-ATP opening by diazoxide effectively …