Polycomb-and methylation-independent roles of EZH2 as a transcription activator
… The polycomb group protein EZH2 is involved in progression of prostate cancer. … In the
present study, we identify the AR as a direct target of EZH2-mediated transcriptional activation in …
present study, we identify the AR as a direct target of EZH2-mediated transcriptional activation in …
Conserved effect of aging on DNA methylation and association with EZH2 polycomb protein in mice and humans
… We performed cross-species comparison of DNA methylation … In humans, DNA methylation
at specific CpG sites can be used … with methyl-CpG binding domain protein followed by high-…
at specific CpG sites can be used … with methyl-CpG binding domain protein followed by high-…
EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization
X Xu, C Wang, J Yang, S Wang, J Dai, L Ye - Epigenetics & chromatin, 2018 - Springer
… time, that EZH2 directly binds to PCNA via the PIP box and promotes methylation at lysine
… Finally, we showed that EZH2 promotes the interaction between DNA polymerase δ (POLδ) …
… Finally, we showed that EZH2 promotes the interaction between DNA polymerase δ (POLδ) …
Structural assembly of Polycomb group protein and Insight of EZH2 in cancer progression: A review
… utility of selective EZH2 inhibitors for the treatment of ER-þ, Tam R breast cancer that expresses
active epigenetic regulator EZH2 and harbors DNA hypermethylation at the specific CpG …
active epigenetic regulator EZH2 and harbors DNA hypermethylation at the specific CpG …
The polycomb group protein EZH2 impairs DNA damage repair gene expression in human uterine fibroids
… This study reveals the important role of EZH2-regulated DNA damage-repair genes via
histone methylation in fibroid biology, and may provide novel therapeutic targets for the medical …
histone methylation in fibroid biology, and may provide novel therapeutic targets for the medical …
The polycomb group protein EZH2 induces epithelial–mesenchymal transition and pluripotent phenotype of gastric cancer cells by binding to PTEN promoter
… Besides promoting cell proliferation and invasion, Ezh2 has a pivotal role in CSC enrichment
and EMT of GC. Most importantly, we show that PTEN is a direct target of Ezh2. Ezh2 binds …
and EMT of GC. Most importantly, we show that PTEN is a direct target of Ezh2. Ezh2 binds …
Regulation of cellular senescence by polycomb chromatin modifiers through distinct DNA damage-and histone methylation-dependent pathways
… p53 (TP53), an important sensor of stresses, including DNA damage. p16 is regulated in
a more complex manner that includes the Polycomb group (PcG) of chromatin regulators ( …
a more complex manner that includes the Polycomb group (PcG) of chromatin regulators ( …
Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys
… devoid of DNA methylation at … DNA methylation valleys (DMVs) or DNA methylation canyons.
However, it remains elusive how most developmental genes can evade DNA methylation …
However, it remains elusive how most developmental genes can evade DNA methylation …
Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies
G Sashida, A Iwama - International journal of hematology, 2017 - Springer
… Promoter DNA hypermethylation has been shown to silence expression of … , Ezh2 loss
caused reduction of H3K27me3 levels at PRC2 target genes, and led to DNA hypermethylation at …
caused reduction of H3K27me3 levels at PRC2 target genes, and led to DNA hypermethylation at …
[HTML][HTML] Targeting DNA methylation and EZH2 activity to overcome melanoma resistance to immunotherapy
… the role that DNA methylation plays in response to ICB and in the regulation of PD-L1, a
main biomarker of ICB responses. We explore whether changes in DNA methylation in CTLs …
main biomarker of ICB responses. We explore whether changes in DNA methylation in CTLs …