… The polycomb group protein EZH2 is involved in progression of prostate cancer. … In the
present study, we identify the AR as a direct target of EZH2-mediated transcriptional activation in …

… We performed cross-species comparison of DNA methylation … In humans, DNA methylation
at specific CpG sites can be used … with methyl-CpG binding domain protein followed by high-…

… time, that EZH2 directly binds to PCNA via the PIP box and promotes methylation at lysine
… Finally, we showed that EZH2 promotes the interaction between DNA polymerase δ (POLδ) …

… utility of selective EZH2 inhibitors for the treatment of ER-þ, Tam R breast cancer that expresses
active epigenetic regulator EZH2 and harbors DNA hypermethylation at the specific CpG …

… This study reveals the important role of EZH2-regulated DNA damage-repair genes via
histone methylation in fibroid biology, and may provide novel therapeutic targets for the medical …

… Besides promoting cell proliferation and invasion, Ezh2 has a pivotal role in CSC enrichment
and EMT of GC. Most importantly, we show that PTEN is a direct target of Ezh2. Ezh2 binds …

… p53 (TP53), an important sensor of stresses, including DNA damage. p16 is regulated in
a more complex manner that includes the Polycomb group (PcG) of chromatin regulators ( …

… devoid of DNA methylation at … DNA methylation valleys (DMVs) or DNA methylation canyons.
However, it remains elusive how most developmental genes can evade DNA methylation …

… Promoter DNA hypermethylation has been shown to silence expression of … , Ezh2 loss
caused reduction of H3K27me3 levels at PRC2 target genes, and led to DNA hypermethylation at …

… the role that DNA methylation plays in response to ICB and in the regulation of PD-L1, a
main biomarker of ICB responses. We explore whether changes in DNA methylation in CTLs …