Cytoskeletal control of B cell responses to antigens

P Tolar - Nature Reviews Immunology, 2017 - nature.com
… pathways that are downstream of the B cell antigen receptor. … B cells, the actin cytoskeleton
is extensively coupled to B cell … Endocytosis and BCR trafficking to degradative compartments …

The coordination between B cell receptor signaling and the actin cytoskeleton during B cell activation

…, Z Yu, Z Peng, X Li, Y Wen, X Sun, B Ren… - Frontiers in …, 2019 - frontiersin.org
… is not required by B cell during antigen recognition (7), so new models should be built to
understand how the mAg is given the priority compared with the sAg. After effective stimulation …

Molecular mechanisms of B cell antigen gathering and endocytosis

R Hoogeboom, P Tolar - B Cell Receptor Signaling, 2016 - Springer
… or trafficking contribute to enhanced B cell activation in … does not require antigen presentation
to T cells. Instead, MZ … actin cytoskeleton, driving changes in B cell shape—flattening of the …

The ins and outs of antigen uptake in B cells

AN McShane, D Malinova - Frontiers in immunology, 2022 - frontiersin.org
… and the role of the actin cytoskeleton and post-translational … of B cell malignancies that
display altered antigen receptor … -antigen endocytosis, trafficking and presentation in B cell

Diacylglycerol kinase ζ promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse

…, AML Dumenil, P Pierobon, J Husson, B Alarcon… - Science …, 2020 - science.org
… immune synapse requires actin cytoskeletal remodeling and … accumulation of antigen-bound
antigen receptors together with … -trafficking events that are required for antigen processing …

Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling

PK Mattila, FD Batista, B Treanor - Journal of Cell Biology, 2016 - rupress.org
… context of immune receptors, such as the B cell receptor, where … the role of the actin
cytoskeleton in controlling receptor … constitutive (tonic) signal necessary for B cell survival, but also …

Dynamics of the membrane–cytoskeleton interface in MHC class II‐restricted antigen presentation

M Bretou, A Kumari, O Malbec… - Immunological …, 2016 - Wiley Online Library
… are required for DCs and B lymphocytes to interact with T cells. … the requirement of an intact
actin cytoskeleton for Ag … also implicated in MHC class II trafficking in B cells 52, 88. On the …

Structurally distinct endocytic pathways for B cell receptors in B lymphocytes

AD Roberts, TM Davenport, AM Dickey… - … Biology of the Cell, 2020 - Am Soc Cell Biol
… We further show that actin recruitment is required for the … The membrane trafficking
pathways that enable B cells to … The cortical actin cytoskeleton, however, has been reported to …

Proteasome dependent actin remodeling facilitates antigen extraction at the immune synapse of B cells

J Ibañez-Vega, F Del Valle Batalla, JJ Saez… - Frontiers in …, 2019 - frontiersin.org
… How B cells balance both pools of actin cytoskeleton to achieve a polarized phenotype … B
cells contain an active proteasome pool at the centrosome, which is required for efficient actin

Role of actin cytoskeleton reorganization in polarized secretory traffic at the immunological synapse

V Calvo, M Izquierdo - Frontiers in cell and developmental biology, 2021 - frontiersin.org
… cluster of antigen receptors bound to antigen called central … IS made by T and B lymphocytes.
The bullseye pattern of a … is required to understand how different immune cells acquire …