[HTML][HTML] Evolution of substrate specificity in the Nucleobase-Ascorbate Transporter (NAT) protein family

A Kourkoulou, AA Pittis, G Diallinas - Microbial Cell, 2018 - ncbi.nlm.nih.gov
L-ascorbic acid (vitamin C) is an essential metabolite in animals and plants due to its role as
an enzyme co-factor and antioxidant activity. In most eukaryotic organisms, L-ascorbate is …

Role of transporters in plant disease resistance

BN Devanna, R Jaswal, PK Singh… - Physiologia …, 2021 - Wiley Online Library
… Members of the NRAMP family belong to the amino acid-polyamine-organocation (APC)
superfamily of secondary carrier proteins and are involved in the transport of divalent metal …

Co-option of a conserved host glutamine transporter facilitates aphid/Buchnera metabolic integration

RP Duncan, CMH Anderson… - Proceedings of the …, 2023 - National Acad Sciences
amino acid cotransporter from the APC Superfamily, using HHPred and Modeller (43, 44).
This analysis showed that ApGLNT1 has the classic APC Superfamily 10 … of APC Superfamily

Comparative Genomics of the Transport Proteins of Ten Lactobacillus Strains

H Zafar, MH Saier Jr - Genes, 2020 - mdpi.com
… Initially, the deficiency of transporters of the APC superfamily may point towards a lack of
competitiveness for acquisition of nutrients; however, the presence of amino acid uptake porters …

Novel insights into the transport mechanism of the human amino acid transporter LAT1 (SLC7A5). Probing critical residues for substrate translocation

L Napolitano, M Galluccio, M Scalise… - … et Biophysica Acta (BBA …, 2017 - Elsevier
… of some members of the amino acid-polyamine-organocation (APC) superfamily was
carried out through the multiple alignment program ClustalW, including 3 amino acid/polyamine …

Consensus mutagenesis approach improves the thermal stability of system xc transporter, xCT, and enables cryo‐EM analyses

K Oda, Y Lee, P Wiriyasermkul, Y Tanaka… - Protein …, 2020 - Wiley Online Library
… The light chain consists of 12 transmembrane helices and belongs to the amino acid-polyamine-organocation
transporter (APC) superfamily. The heavy chain has a large extracellular …

Eisosomes at the intersection of TORC1 and TORC2 regulation

M Babst - Traffic, 2019 - Wiley Online Library
… One group of proteins that responds very strongly to environmental changes is the protein
superfamily of the amino acid polyamine organocation (APC) type nutrient transporters. These …

Transport of amino acids across the vacuolar membrane of yeast: its mechanism and physiological role

M Kawano-Kawada, Y Kakinuma… - Biological and …, 2018 - jstage.jst.go.jp
amino acidpolyamineorganocation (APC) transporter family participate in the uptake of
extracellular amino … -coupled receptor (TOG) superfamily, possess putative 7 transmembrane …

Both chloride-binding sites are required for KCC2-mediated transport

L Becker, J Hausmann, AM Hartmann - Journal of Biological Chemistry, 2023 - ASBMB
… This fold is highly conserved within the amino acid/polyamine/organocation superfamily.
A family within this superfamily is the cation chloride cotransporter (CCC) family ( …

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino …

H Ilgü, JM Jeckelmann, C Colas, Z Ucurum… - International journal of …, 2018 - mdpi.com
… AdiC belongs to the amino acid/polyamine/organocation (APC) transporter superfamily [2]
and is a prokaryotic homolog of the human SLC7 family of amino acid transporters [3]. …