… response to environmental stresses. In particular, we focus on the multiple stress-sensing
mechanisms of … Our body is equipped with a defense system that up-regulates the expression …

… the mechanisms by which Keap1 orchestrates the antioxidant … The Keap1-Nrf2 system is
responsive to a wide range of … The general notion is that several sensor cysteine residues …

… of a response based on a derepression mechanism is an … how NRF2 is ubiquitinated
under normal conditions, multiple … detoxication and antioxidant defense responses, thereby …

… -to-day biological response to oxidative stress is the Kelch-… transcription of many several
antioxidant genes that preserve … involved in inflammation, and antioxidant defense system [167]. …

… other mechanisms [6]. One limitation of this study, which is in fact shared with several other
… , and they rely on their own antioxidant response as well as that of neighboring astrocytes to …

… Furthermore, we highlight several major signals involved in … the activity of components of
antioxidant defense, such as … triggering a protective antioxidant response. Under oxidative …

… stress response,’’ the molecular identity of the H2O2 sensor in the Keap1-Nrf2 system is …
Our present findings also provide insights into the multiple sensing mechanisms used to …

… mechanisms how the KEAP1-NRF2 system senses and regulates the cellular response is
… Nonetheless, how KEAP1 senses a variety of chemicals utilizing multiple and distinct sets of …

… In response to oxidants, the DLG motif in Nrf2 is released … The effect is due to the presence
of several κB sites in Nrf2 … /or defective antioxidant defense mechanisms in aging myoblasts …

… to switch the experimental system to mouse Keap1-Nrf2 for our … BTB domain is important
for Nrf2 activation in response to … into the multiple sensing mechanisms for the detection of …