… β-Adrenergic receptor dysfunction plays a crucial role in heart failure pathogenesis,
participating in the … Reactivation of β-adrenergic receptor signaling in heart failure is therapeutic. …

… In this review, we will focus on the alterations of beta-adrenergic signaling in the heart in
the context of environmental stress, aging, and heart failure. We also address the putative …

… Beta-adrenergic receptors (β-ARs) are members of a large family of cell surface receptors
known as G-protein-coupled receptors (… in the presence of cardiac ryanodine receptor (RyR2) …

… a potential target for the treatment of heart disease. Based on these findings, clinical … in
patients with heart failure to evaluate whether β 3 -AR stimulation has beneficial effects on failing …

… (ABs) to treat cardiovascular disease has been predominantly a story of failure. In the …
Lowering Treatment to Prevent Heart Attack Trial) hypertension trial, incident heart failure (HF) was …

… for patients having systemic hypertension (HTN) who have concomitant ischemic heart
disease (IHD), heart failure, obstructive cardiomyopathy, aortic dissection or certain cardiac …

… death, cardiac transplantation, or hospitalization due to exacerbation of heart failure in patients
with low NYHA functional class, but (B) significance was seen in sicker patients. *p = 0.02 …

… Cardiovascular diseases include the heart and blood vessel; others are stroke, cardiomyopathy,
congenital heart disease, and … Heart failure is associated with impaired cardiac vagal …

… in heart failure (21). … patients with higher anti-ß-AR Ab levels might be an innate Ab
upregulation with an agonistic effect on the beta-adrenergic receptors in order to overcome cardiac …

… failure. Patients with heart failure and baseline LVEF ≤ 40% were genotyped (n = 98), and
… In conclusion, patients with heart failure and reduced ejection fraction that are homozygous …