mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
SH Jung, HJ Hwang, D Kang, HA Park, HC Lee… - Oncogene, 2019 - nature.com
… Here, we set out identify the critical relay molecule that lies between PI3K/AKT and p53 in …
[18], and Rapa treatment converts nutlin-3a-induced senescence into quiescence [18]. Astle …
[18], and Rapa treatment converts nutlin-3a-induced senescence into quiescence [18]. Astle …
The cell fate: senescence or quiescence
… On the other hand, quiescent is a cell cycle arrest and defined … in quiescent cells since
mTOR pathway is inhibited. [5]. … This finding has shed light on that p53-induced senescence …
mTOR pathway is inhibited. [5]. … This finding has shed light on that p53-induced senescence …
Inhibition of mTOR signaling enhances maturation of cardiomyocytes derived from human-induced pluripotent stem cells via p53-induced quiescence
… the cell cycle proceed to quiescence versus senescence, a state of … in this study and provided
a determination of not human subjects … This effect appears to be driven at least in part by …
a determination of not human subjects … This effect appears to be driven at least in part by …
[HTML][HTML] p53 and metabolism: from mechanism to therapeutics
… PI3K/AKT/mTOR pathway and/or ROS induction. The interplay … Accordingly, part of the
glucose consumed through the … that overexpression of p53 induced cell transformation and p53 …
glucose consumed through the … that overexpression of p53 induced cell transformation and p53 …
[HTML][HTML] Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging
… by more defined premature aging phenotypes in addition to aging-… senescence into
quiescence by inhibiting the mTOR pathway, suggesting that p53 may also have the anti-aging …
quiescence by inhibiting the mTOR pathway, suggesting that p53 may also have the anti-aging …
[HTML][HTML] Do p53 stress responses impact organismal aging?
P Hasty, J Campisi, ZD Sharp - Translational cancer research, 2016 - ncbi.nlm.nih.gov
… p53 transcribes a diverse set of genes that promote apoptosis (… quiescence in response to
stress, and suppresses mTORC1-… deficiency resulted in p53-induced senescence in epidermal …
stress, and suppresses mTORC1-… deficiency resulted in p53-induced senescence in epidermal …
[HTML][HTML] Sirt3 activates autophagy to prevent DOX-induced senescence by inactivating PI3K/AKT/mTOR pathway in A549 cells
X Fan, Y He, G Wu, H Chen, X Cheng, Y Zhan… - … et Biophysica Acta (BBA …, 2023 - Elsevier
… We next assessed whether DOX-induced senescence was associated with cellular ROS …
Therefore, we assessed mitochondrial function by detecting mitochondrial membrane potential (…
Therefore, we assessed mitochondrial function by detecting mitochondrial membrane potential (…
[HTML][HTML] The IGF-1R/AKT pathway determines cell fate in response to p53
L Duan, CG Maki - Translational cancer research, 2016 - ncbi.nlm.nih.gov
… P53 induced by stress can promote survival, senescence, or … , p53-dependent senescent
arrest into a reversible, quiescent … /mTORC1 pathway activation can determine the choice of …
arrest into a reversible, quiescent … /mTORC1 pathway activation can determine the choice of …
Senescence-associated secretory phenotype regulated by mTOR pathway in senescent cells
S Maslyaeva - 2024 - dspace.cuni.cz
… The choice between senescence and quiescence is determined by the activity … Choice
between P53-Induced Senescence and Quiescence Is Determined in Part by the MTOR Pathway.…
between P53-Induced Senescence and Quiescence Is Determined in Part by the MTOR Pathway.…
Rapamycin, proliferation and geroconversion to senescence
MV Blagosklonny - Cell cycle, 2018 - Taylor & Francis
… mTOR drives conversion from quiescence to senescence (… is driven in part by the
growth-promoting mTOR pathway [Citation1,… Although senescence can be defined as arrest that is …
growth-promoting mTOR pathway [Citation1,… Although senescence can be defined as arrest that is …