Surfactant replacement therapy: from biological basis to current clinical practice

R Hentschel, K Bohlin, A van Kaam, H Fuchs… - Pediatric …, 2020 - nature.com
… This review summarizes the current knowledge on the physiological action of endogenous
and exogenous pulmonary surfactant, the role of different types of animal-derived and …

[HTML][HTML] A recipe for a good clinical pulmonary surfactant

J Pérez-Gil - biomedical journal, 2022 - Elsevier
current concepts on the compositional and structural determinants defining pulmonary
surfactant … -derived or recombinant or synthetic therapeutic surfactants, as well as a the most …

Surfactants in acute respiratory distress syndrome in infants and children: past, present and future

A Amigoni, A Pettenazzo, V Stritoni, M Circelli - Clinical drug investigation, 2017 - Springer
… Natural pulmonary surfactant plays an essential role in lung physiology; it is responsible
for lowering surface tension within the alveoli and maintaining the functional integrity of the …

Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins

R Guagliardo, J Perez-Gil, S De Smedt… - Journal of Controlled …, 2018 - Elsevier
… use of (clinical) pulmonary surfactant as a drug carrier to promote drug spreading and
transport along the alveolar interface. Next, each lung surfactant protein will be introduced from a …

[HTML][HTML] Structural hallmarks of lung surfactant: Lipid-protein interactions, membrane structure and future challenges

JC Castillo-Sánchez, A Cruz, J Pérez-Gil - Archives of biochemistry and …, 2021 - Elsevier
Lung surfactant (LS) is an outstanding example of how a highly regulated and dynamic …
stabilizes the respiratory air-liquid interface in the mammalian lung. The present review dissects …

Composition, Structure and Biophysical Functions of Pulmonary Surfactants: Their Deficiency and Strategy for Remedy

AK Panda - 2017 - insajournal.in
Pulmonary surfactant (PS) is a complex mixture of lipids and proteins that forms a monomolecular
film at the lung… A brief account of the evolutionary development of pulmonary surfactant

New insights into exogenous surfactant as a carrier of pulmonary therapeutics

B Baer, LMP Souza, AS Pimentel… - Biochemical …, 2019 - Elsevier
… Similarly, molecular dynamics simulations of clarithromycin interacting with a lung surfactant
model provide evidence that clarithromycin may be incorporated into the lung surfactant

The Lord of the Lungs: The essential role of pulmonary surfactant upon inhalation of nanoparticles

C Garcia-Mouton, A Hidalgo, A Cruz… - European Journal of …, 2019 - Elsevier
… compromise the respiratory function. This review explains the key role of pulmonary surfactant
to … with surfactant and unravelling the mutual effects. The implication of the nanoparticle-…

Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
pulmonary surfactantpulmonary surfactant stabilizes our alveoli has still not been achieved.
It has long been suggested (but not always accepted) that the ability of pulmonary surfactant

Recent progress on surfactant protein A: cellular function in lung and kidney disease development

SD King, SY Chen - American Journal of Physiology-Cell …, 2020 - journals.physiology.org
… In this mini-review, we discuss SP-A functions and the consequences of SP-A genetic
mutations or pulmonary surfactant deficiencies, with a specific emphasis on the recent progress in …