… 5, the optimal co-transcriptional assembly of the messenger … observed that RNA–DNA
hybrids that cause genome instability … the important role of DDR in preventing DNA–RNA hybrid …

… in gene expression could challenge co-transcriptional proc… a role for R-loops in E2-induced
DNA damage and reveal a … contribution of co-transcriptional RNA:DNA hybrid structures …

… We also discuss how hybrids could contribute to cancer, … /RNA:DNA hybrid formation and
their impact on genome instability … Thus, the co-transcriptional processing of nascent transcripts …

… role of DHX9 in maintaining genome stability. DHX9 interacts with PARP1, and the loss
of these proteins leads to R-loop accumulation, which triggers DNA damage… co-transcriptional …

… source of genomic instability, highlighting the importance of proper regulation of R-loops. …
RNA–DNA hybrids in vitro and suppresses co-transcriptional R-loops throughout the genome …

… that DNA:RNA hybrids compromising genome integrity are … coating protects DNA from
co-transcriptional RNA hybridization. … role of the recombination protein Rad51 in DNA:RNA hybrid…

… sites and participate in the DNA damage response. Here, we … on genome stability, the
role of RNA binding proteins at DNA damage sites, and the function of small non-coding RNAs …

… cells, but its co-transcriptional deposition and functions … RNA helicase DDX21 with a
previously unrecognized role in directing m 6 A modification on nascent RNA for co-transcriptional …

… cycle with different consequences for replication and genome integrity. … role of mRNA coating
and supercoiling in the prevention of DNA-RNA hybridization, co-transcriptional DNA-RNA …

… with the template strand and remain trapped in RNA-DNA hybrid structures. (Figure 7) …
Yeast Pif1 has been shown to unwind RNA:DNA hybrids and maintain genome stability at G-…