… that NSAIDs can prevent colorectal neoplastic progression, … -2 inhibitor, celecoxib, 77
suggesting COX-2 inhibitors can … Thus, rofecoxib and valdecoxib were withdrawn from the …

… mainly in inflamed and neoplastic tissue. Some inflammation … that inhibiting COX-2 expression
with celecoxib promotes … oral nonselective and cyclooxygenase-2-selective nsaids on …

… The strength of this study is that we took a comprehensive research on the efficacy of
selective COX-2 inhibitor use for the prevention and treatment of GI malignancies, including the …

… COX-2 inhibitors such as rofecoxib originate from their … , central nervous system, and
colorectal neoplastic tissues, an … -2 inhibitors compared with the reference drug celecoxib. Further…

… COX-2 was proved to be increased in colorectal neoplasia compared with patients without
… prevention. Systemic COX-2 inhibitors, like celecoxib and rofecoxib, have great efficacy in …

There is still insufficient data about the risk-benefit profile about recommending non-aspirin,
non-steroidal anti-inflammatory drugs (NA-NSAIDs) for colorectal cancer (CRC) prevention, …

… Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain
… , which help to improve the bioavailability and avoid effects of long drug administrations. For …

… Celecoxib and rofecoxib were first studied in FAP patients … high-dose celecoxib in preventing
colorectal adenomas thus … chemically or genetically induced colorectal neoplasia, in which …

… and micronuclei yielding macroscopically visible neoplasms [6]. Chemically … Cyclooxygenase-2
selective non-steroidal antiinflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib…

… prostaglandins synthesis in inflamed and neoplastic tissues [11]… nimesulide, etodolac,
celecoxib, rofecoxib (discontinued) and … Rofecoxib Pancreatic Evaluation of the role of rofecoxib in …