… to COX-2-targeted treatment in EMS, including COX-2 inhibitors… mainly involved in extracellular
matrix degradation to promote … of estrogen, which alone activates COX-2 and NF-κB to …

… Degradation of the extracellular matrix (ECM) is closely … the mRNA expression of the PGE2
downstream receptors (EP1, EP2, EP3 and EP4) by PCR assay shows that EP2 and EP4 are …

… EP3 antagonist) induces the expression of estrogen receptor β and … The mRNA expressions
of COX-1, COX-2, EP2 and EP4 are … COX-1, COX-2, mPGES-1, EP1 and EP2 are expressed …

… , featuring increased local production of estrogen as well as … the gene and protein expression
levels of COX-2, EP2, and EP4 … Finally, to cross-link the extracellular matrix (ECM) protein (…

… ], and gene expression profiling showed high levels COX2 and MRP4 and low levels of PGT
… upregulating intracellular calcium concentration; EP2 and EP4 can form a heterodimer and …

… Degradation of the extracellular matrix is a … COX-2 expression, PGE 2 release, EP4
expression and c-Src phosphorylation. Ohtake et al. [54] reported that gene expression by estrogen …

… , which are associated with the gene expression of prolactin (PRL) and the … expression of
EP1, EP2, EP4 and COX-2 in the HTR-8/SVneo trophoblast cell line [74]. Expression of COX-2 …

… [19] leading to remodeling of the extracellular matrix [20, 21] 85 … The expression of ER
alpha, OTR, cPLA(2), COX-2, and PPAR 621 … Differential estradiol 639 effects on estrogen and …

… and mRNA expression levels of COX-1, COX-2 and EP4 were … The mean mRNA levels
of COX-1, COX-2 and EP4 were … -estradiol increased the mRNA expressions of COX-2 and …

… Endometrial stromal cells within proper extracellular matrices … of COX-2 by activating COX-2
transcription and stabilizing … feedback loop of COX-2/PGE2 and estrogen in endometriosis …