Short chain fatty acids in human gut and metabolic health

EE Blaak, EE Canfora, S Theis, G Frost… - Beneficial …, 2020 - wageningenacademic.com
… (eg oral vs intragastric infusions vs colonic infusions vs gut microbial … Only a few gut bacteria
can use long-chain or complex … the effect of propionate on food intake in humans, there are …

Short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

PA Gill, MC Van Zelm, JG Muir… - Alimentary …, 2018 - Wiley Online Library
Long-chain fatty acids and pyruvate may be converted to acetyl-CoA, which is then broken
… , butyrate infusion into the distal colon of rats had no specific effect over saline infusions on …

[HTML][HTML] Effects of intraduodenal administration of lauric acid and L-tryptophan, alone and combined, on gut hormones, pyloric pressures, and energy intake in healthy …

C McVeay, PCE Fitzgerald, SS Ullrich… - The American Journal of …, 2019 - Elsevier
… the infusions, energy intake from a standardized buffet meal … For example, in healthy humans
the intraduodenal infusion (… with C12 stimulating free fatty acid receptors and Trp activating …

[HTML][HTML] Activation of short and long chain fatty acid sensing machinery in the ileum lowers glucose production in vivo

M Zadeh-Tahmasebi, FA Duca, BA Rasmussen… - Journal of Biological …, 2016 - ASBMB
… the myriad of ways the gut microbiota influences host energy … in humans and rodents,
including improvements in glucose … uptake during intraileal fatty acid infusions. The experiments …

Intestinal delivery in a long-chain fatty acid formulation enables lymphatic transport and systemic exposure of orlistat

G Lee, S Han, Z Lu, J Hong, ARJ Phillips… - International Journal of …, 2021 - Elsevier
intestinal administration in lipid formulations (LFs). The effect of lipid type, lipid dose, orlistat
dose, and infusion time … For example, in healthy volunteers and human patients, the plasma …

[HTML][HTML] Dietary medium-chain fatty acids reduce food intake via the GDF15-GFRAL axis in mice

JM Kanta, L Deisen, K Johann, S Holm… - Molecular …, 2023 - Elsevier
… Hepatic and small intestinal expression of Gdf15 and … , while intake of typical dietary long-chain
fatty acids (LCFAs) had no … vein infusion reduced food intake during the first meal by 40…

[HTML][HTML] Saturated long-chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats

L Zhao, Y Huang, L Lu, W Yang, T Huang, Z Lin, C Lin… - Microbiome, 2018 - Springer
GI motility in humans, most of studies concerned their effects … men showed that upper
intestinal infusion of oils enriched … LCFA-induced slower upper GI motility influences food intake

Effects of intraduodenal coadministration of lauric acid and leucine on gut motility, plasma cholecystokinin, and energy intake in healthy men

C McVeay, RE Steinert… - American Journal …, 2020 - journals.physiology.org
… In our recent study, intraduodenal infusion of a combination of C12 … Effects of intraduodenal
fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans

[HTML][HTML] The short-chain fatty acid acetate in body weight control and insulin sensitivity

MA González Hernández, EE Canfora, JWE Jocken… - Nutrients, 2019 - mdpi.com
… acetate infusions have shown pronounced increments in gut … T2DM subjects, acetate
intravenous infusions (2.5 mmol per … that acetate might replace long chain fatty acids as preferred …

[HTML][HTML] Odd chain fatty acids; new insights of the relationship between the gut microbiota, dietary intake, biosynthesis and glucose intolerance

BJ Jenkins, K Seyssel, S Chiu, PH Pan, SY Lin… - Scientific reports, 2017 - nature.com
human intervention studies, we comprehensively investigated all possible contributions of
these fatty acids from the gut-microbiota, the diet… :0 infusion study in rats to assess the effect on …