The therapeutic potential of gelsolin in attenuating cytokine storm, ARDS, and ALI in severe COVID-19

J Zhi, KX Zhao, JH Liu, D Yang, XM Deng… - Frontiers in …, 2024 - frontiersin.org
… -19-induced ALI/ARDS and non-COVID-19 ALI/ARDS, it is … of GSN treatment need to be
established through well-… , GSN-based therapies may become a reality in the near future, offering …

Corticosteroids in acute lung injury: the dilemma continues

D Mokra, P Mikolka, P Kosutova, J Mokry - International journal of …, 2019 - mdpi.com
… cells in the direct ALI/ARDS, surfactant protein D has been … more prominent in the indirect
ALI/ARDS can be confirmed by … supplemental oxygen at ICU transfer, while CS therapy was …

Biomarkers for patients with trauma associated acute respiratory distress syndrome

W Xu, Y Song - Military Medical Research, 2017 - Springer
… Pulmonary surfactant proteins are specifically secreted by … pro-inflammation factor during
ALI/ARDS. Extracellular histones … mortality must be included in future new trial because these …

Preclinical and clinical studies of smoke-inhalation-induced acute lung injury: update on both pathogenesis and innovative therapy

B Guo, Y Bai, Y Ma, C Liu, S Wang… - Therapeutic …, 2019 - journals.sagepub.com
Future directions and further needs for developing innovative … and reduce the amount of
pulmonary surfactant (PS), leading … , (b) applying MSCs in ALI/ARDS, and (c) regenerative …

Acute respiratory distress syndrome: bench‐to‐bedside approaches to improve drug development

M Hussain, C Xu, M Ahmad, A Majeed… - Clinical …, 2018 - Wiley Online Library
therapies that warrant further testing, and future therapeutic … integrity, attenuation of surfactant
production, and inhibition of … , the therapeutic effectiveness of sivelestat to treat ALI/ARDS

Evolution of validated biomarkers and intraoperative parameters in the development of postoperative ARDS

H Yadav, A Bartley, S Keating, LA Meade… - Respiratory …, 2018 - rc.rcjournal.com
… ARDS through a temporal analysis of key biomarkers of interest. … Future studies could use
the most promising candidate biomarkers in this study (PAI-1, IL-8, and surfactant protein-D) in …

Adult respiratory distress syndrome

S Cutts, R Talboys, C Paspula… - The Annals of The …, 2017 - publishing.rcseng.ac.uk
At present, no single treatment has been shown to modify the … Exogenous surfactant may
improve oxygenation but, again, … that there may be a future in gene therapy. No such agent is …

Glucocorticoid treatment in acute respiratory distress syndrome: An overview on mechanistic insights and clinical benefit

J Zhang, P Ge, J Liu, Y Luo, H Guo, G Zhang… - International Journal of …, 2023 - mdpi.com
while considering the damaged intestinal barrier and respiratory failure, which undoubtedly
increases the difficulty of the diagnosis and treatment of SAP-ALI/ARDS… inform future studies …

[图书][B] Nebulized anti-coagulants as a therapy for acute lung injury and acute respiratory distress syndrome

M Camprubí-Rimblas - 2018 - ddd.uab.cat
… endogenous substances like surfactant or apoptotic or necrotic cells. At the pulmonary …
factors VIIa and thrombin are found in the injured lungs of patients with ALI/ARDS [79, 80]. …

Effect of sivelestat sodium in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of randomized controlled trials

S Pu, D Wang, D Liu, Y Zhao, D Qi, J He… - BMC pulmonary …, 2017 - Springer
… by ventilator due to surfactant deficiency and dysfunction, which … the effect of sivelestat
therapy in patients with ALI/ARDS. Six … Future large-scale trials should focus on different disease …