The impact of aminophylline on incidence and severity of post-dural puncture headache: a meta-analysis of randomised controlled trials
Background This meta-analysis aimed at addressing the impact of aminophylline use on risk
and severity of post-dural puncture headache (PDPH). Methods Electronic databases (ie,
Medline, Embase, and the Cochrane controlled trials register) were searched from inception
to the 12 th of January 2021 for randomised controlled trials (RCTs) that assessed the
efficacy of aminophylline for treatment (ie, primary outcome) or prophylaxis (ie, secondary
outcome) against PDPH in various clinical settings. The study is registered with PROSPERO …
and severity of post-dural puncture headache (PDPH). Methods Electronic databases (ie,
Medline, Embase, and the Cochrane controlled trials register) were searched from inception
to the 12 th of January 2021 for randomised controlled trials (RCTs) that assessed the
efficacy of aminophylline for treatment (ie, primary outcome) or prophylaxis (ie, secondary
outcome) against PDPH in various clinical settings. The study is registered with PROSPERO …
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