Kinesin-8 motors: regulation of microtubule dynamics and chromosome movements

Y Lin, YL Wei, ZY She - Chromosoma, 2020 - Springer
… that KIF18A depletion reduces the velocity of kinetochore … fibers for chromosome congression
and alignment. In human cells, … KIF18A inhibits microtubule dynamics and also suppresses

Biomechanics of chromosome alignment at the spindle midplane

P Risteski, M Jagrić, N Pavin, IM Tolić - Current biology, 2021 - cell.com
… to ensure synchronous poleward movement of chromatids in … exerted onto sister kinetochores
by kinetochore microtubules, … chromosomes due to co-depletion of Kif18A/kinesin-8 and …

Structural basis of human kinesin-8 function and inhibition

J Locke, AP Joseph, A Peña… - Proceedings of the …, 2017 - National Acad Sciences
Kif18A mainly functions during mitotic chromosome positioning by regulating kinetochore
-1 has been identified as an inhibitor that specifically inhibits Kif18A (38). Interestingly, and in …

Microtubule end tethering of a processive kinesin-8 motor Kif18b is required for spindle positioning

T McHugh, AA Gluszek, JPI Welburn - Journal of Cell Biology, 2018 - rupress.org
… Typically, Kif18a targets to K-fibers and kinetochores, … , the N-terminal GFP tag inhibits the
motile properties of Kif18b, … GFP constructs was obtained by aligning EB1 comet profiles with …

Kif18A promotes Hec1 dephosphorylation to coordinate chromosome alignment with kinetochore microtubule attachment

H Kim, J Stumpff - Biorxiv, 2018 - biorxiv.org
Kif18A (kinesin-8) suppresses the dynamics of kinetochore … , where it confines chromosome
movements and promotes the … indicates that the kinesin-8 motor Kif18A recruits PP1 and …

Drosophila kinesin-8 stabilizes the kinetochore–microtubule interaction

T Edzuka, G Goshima - Journal of Cell Biology, 2019 - rupress.org
Kinesin-8 is required for proper chromosome alignment in a … We show that human kinesin-8
(KIF18A) is also important to … by other means might partially suppress the MT detachment …

Metaphase kinetochore movements are regulated by kinesin-8 motors and microtubule dynamic instability

AH Klemm, A Bosilj, M Gluncic, N Pavin… - Molecular biology of the …, 2018 - Am Soc Cell Biol
… how kinesin-8 motors are distributed along MTs in mitosis, we … The data are aligned to the
time and kinetochore position … to suppress nmt81-promotor regulated GFP-atb2 expression. …

Evidence of kinesin motors involved in stable kinetochore assembly during early meiosis

S Shah, P Mittal, D Kumar, A Mittal… - Molecular Biology of the …, 2023 - Am Soc Cell Biol
kinetochores while kinesin 8 and Kip3 resides at all the … resolution and movement of the
chromosomes (kinetochores) towards … Despite the difference in kinetochore alignment along the …

[图书][B] Temporal Coordination Of Mitotic Chromosome Alignment And Segregation: Structural And Functional Studies Of Kif18a

H Kim - 2018 - search.proquest.com
… Interestingly, HeLa cells depleted of a kinesin-8 motor Kif18A… as Kif18A’s function in
chromosome alignment is to suppress … We find that Kif18A is required to stabilize kinetochore-MT …

Emerging insights into the function of kinesin-8 proteins in microtubule length regulation

S Shrestha, M Hazelbaker, AL Yount, CE Walczak - Biomolecules, 2018 - mdpi.com
… is critical for localization of Kif18A at kinetochore MT plus ends [… the functions of Kif18A in
chromosome alignment [95]. In a … the Kinesin-8 protein, particularly human Kif18A, suppresses