Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia
RS Dos Reis, S Sant, H Keeney, MCE Wagner… - Scientific reports, 2020 - nature.com
… -induced neuropathogenesis; however, such model has not yet been explored for HIV-1
infection to … We further tested the ability of these hBORGs to support HIV-1 infection as well as to …
infection to … We further tested the ability of these hBORGs to support HIV-1 infection as well as to …
Neuropathogenesis of HIV-1: insights from across the spectrum of acute through long-term treated infection
L Killingsworth, S Spudich - Seminars in immunopathology, 2022 - Springer
… neuropathogenesis of HIV, from initial HIV entry into the central nervous system (CNS) to
chronic infection… Discoveries regarding acute HIV infection reveal timing and mechanisms of …
chronic infection… Discoveries regarding acute HIV infection reveal timing and mechanisms of …
Defining the roles for Vpr in HIV-1-associated neuropathogenesis
T James, MR Nonnemacher, B Wigdahl… - Journal of …, 2016 - Springer
… can be expanded further through (i) naturally occurring HIV-1 … delivered and expressed
during HIV-1 infection and as an … Neuropathogenesis associated with HIV-1 infection is clearly …
during HIV-1 infection and as an … Neuropathogenesis associated with HIV-1 infection is clearly …
HIV neuropathology
S Morgello - Handbook of clinical neurology, 2018 - Elsevier
… What is clear with regard to neuropathogenesis is that the predominant cellular location
of infection in untreated HIVE is in multi- and mononucleated monocytes/macrophages and …
of infection in untreated HIVE is in multi- and mononucleated monocytes/macrophages and …
Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis
… 1 (HIV-1) infection. However, recent studies indicate that considerably more than 50% of all
HIV-1 infected patients develop HIV-1-… to neuropathogenesis during primary HIV infection by …
HIV-1 infected patients develop HIV-1-… to neuropathogenesis during primary HIV infection by …
New challenges of HIV-1 infection: how HIV-1 attacks and resides in the central nervous system
… triggered by the altered balance of CaMKIIβ and glycogen synthase kinase 3β (GSK3β);
this interaction is implicated in oligodendrocyte apoptosis as well as HIV-1 neuropathology [93]. …
this interaction is implicated in oligodendrocyte apoptosis as well as HIV-1 neuropathology [93]. …
Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysregulates neurogranin and induces synaptodendritic injury
… This is the first study evaluating the expression and functional role of Ng in the context of
HIV-1 neuropathogenesis. Here, we demonstrate that HIV-1 infection decreases the level of Ng …
HIV-1 neuropathogenesis. Here, we demonstrate that HIV-1 infection decreases the level of Ng …
The role of shed PrPc in the neuropathogenesis of HIV infection
BW Megra, EA Eugenin, JW Berman - The Journal of Immunology, 2017 - journals.aai.org
… A total of 250,000 uninfected or HIV-1 ADA –infected primary human monocytes from our
culture system (see 2Materials and Methods) in RPMI 1640 supplemented with 2% FBS were …
culture system (see 2Materials and Methods) in RPMI 1640 supplemented with 2% FBS were …
Neuropathogenesis of human immunodeficiency virus infection
B Sillman, C Woldstad, J Mcmillan… - Handbook of clinical …, 2018 - Elsevier
… immunodeficiency type 1 (HIV-1) infection. Alterations in brain … -infected monocytes and
macrophages lead to compromise of the structural integrity of the BBB following HIV-1 infection …
macrophages lead to compromise of the structural integrity of the BBB following HIV-1 infection …
Neuroimaging the Neuropathogenesis of HIV
… This review highlights neuroimaging studies of HIV conducted over the last 2 years and
discusses how relevant findings further our knowledge of the neuropathology of HIV. Three …
discusses how relevant findings further our knowledge of the neuropathology of HIV. Three …