… movement of helices needed for ion flow or by inducing structural rearrangements that block
… solution to harvest useful information from many known weak inhibitors of ion channels. …

… The hepatitis C caused by the hepatitis C virus (HCV) is an acute and/or chronic liver disease
… clinical practice of the direct acting antiviral (DAA) agents targeting the non-structural viral …

… to block its activity, which hold p7 high as a potential antiviral target in … BIT225 displays a
higher potency in the antiviral activity … [26] suppress HCV p7 ion channel signals at μM range …

… strain) p7, we suggest that HCV p7 can specifically interact with PS, and this interaction
induces membrane permeabilization, which is blocked by nonselective ion channel blockers. …

… Abstract Since the 1960s, a single class of agent has been licensed targeting virus-encoded
ion channels, or ‘viroporins’, contrasting the success of channel blocking drugs in other …

… p7 protein of hepatitis C virus (HCV) is an intracellular ion … Indeed, p7 inhibitors have been
identified as antiviral agents, … ion channel function of the p7 protein directly. Genotype-specific …

… HCV p7 channel make it an attractive target for antiviral inhibitor … that blocking NTD of p7
channel for inhibiting HCV infection. … A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, …

… Protein p7 of hepatitis C virus (HCV) is a short 63 amino acid membrane protein which
homo-oligomerises in the lipid membrane to form ion and proton conducting bundles. Two …

… a hexameric p7 ion channel by examining ion translocation in a … antivirals targeting HCV
have dramatically improved antiviral … , is obviously not sufficient to block the permeation of water …

… antiviral agents have been designed against hepatitis C virus, … developing HCV direct-acting
antiviral agents is proposed by … on HCV p7 protein, a cation-selective ion channel [10]. This …