… In summary, involvement of the polycystins in ADPKD has underscored the importance of
these proteins in normal renal function. The fundamental research studies that followed the …

… The major autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2…
PKD1 encodes polycystin 1 (PC1), a large membrane associated receptor-like protein that …

… called cysts. The causal genes PKD1 and PKD2 encode transmembrane proteins polycystin
1 (PC1) and polycystin 2 (… offer exciting prospects for novel discoveries for the next phase of …

… Polycystin-1 (PC1) PC1 is predicted to be a large, membrane-associated protein with a …
In addition, ~60% of mutations are missense (with ~40% truncating), and as is typical for novel …

… for polycystins domain, is conserved in polycystins and is … protein, polycystin-2 (PC2). PC2
is a member of the transient receptor potential protein family, with 6 TMs, a novel polycystin-…

… polycystins are widely expressed in tissues other than kidney. … , ligand, and/or
membrane-associated enzyme [Citation82]. … to be discussed are HNF1ß, novel genes for ARPKD …

… polarity, resulting in the formation of renal cysts. The PKD1 gene mutation accounts for …
(GPS) within polycystin-1, a membrane protein with distinct peptide domains implicated in cell-…

… , which encodes the polycystin-1 (PC-1) protein, remain the … by heterotrimeric G proteins or
the identification of novel signaling … activation of membrane-associated exchange protein 1/2 (…

… the encoded proteins (polycystin-1 and polycystin-2). Polycystin 1 is an adhesion type G
protein … HDAC inhibitor alone or the combination of HDAC inhibitor and tolvaptan may be novel …

… protein diffusion into the cilium.54, 55 In the case of RP2, a membrane-associated protein that
… We have developed a novel method that allows us to strip the extracellular, noncovalently …