The Polycystins and Polycystic Kidney Disease
BL Blazer-Yost, DP Wallace - … of Epithelia in Health and Disease-Vol. 3, 2020 - Springer
… In summary, involvement of the polycystins in ADPKD has underscored the importance of
these proteins in normal renal function. The fundamental research studies that followed the …
these proteins in normal renal function. The fundamental research studies that followed the …
Regulation of polycystin expression, maturation and trafficking
J Hu, PC Harris - Cellular signalling, 2020 - Elsevier
… The major autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2…
PKD1 encodes polycystin 1 (PC1), a large membrane associated receptor-like protein that …
PKD1 encodes polycystin 1 (PC1), a large membrane associated receptor-like protein that …
Ciliary mechanisms of cyst formation in polycystic kidney disease
M Ma, AR Gallagher, S Somlo - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
… called cysts. The causal genes PKD1 and PKD2 encode transmembrane proteins polycystin
1 (PC1) and polycystin 2 (… offer exciting prospects for novel discoveries for the next phase of …
1 (PC1) and polycystin 2 (… offer exciting prospects for novel discoveries for the next phase of …
Classical polycystic kidney disease: gene structures and mutations and protein structures and functions
E Cornec-Le Gall, PC Harris - Polycystic Kidney Disease: Translating …, 2018 - Springer
… Polycystin-1 (PC1) PC1 is predicted to be a large, membrane-associated protein with a …
In addition, ~60% of mutations are missense (with ~40% truncating), and as is typical for novel …
In addition, ~60% of mutations are missense (with ~40% truncating), and as is typical for novel …
Mechanisms of cyst development in polycystic kidney disease
J Qiu, GG Germino, LF Menezes - Advances in kidney disease and health, 2023 - Elsevier
… for polycystins domain, is conserved in polycystins and is … protein, polycystin-2 (PC2). PC2
is a member of the transient receptor potential protein family, with 6 TMs, a novel polycystin-…
is a member of the transient receptor potential protein family, with 6 TMs, a novel polycystin-…
Recent advances in the molecular diagnosis of polycystic kidney disease
C Bergmann - Expert review of molecular diagnostics, 2017 - Taylor & Francis
… polycystins are widely expressed in tissues other than kidney. … , ligand, and/or
membrane-associated enzyme [Citation82]. … to be discussed are HNF1ß, novel genes for ARPKD …
membrane-associated enzyme [Citation82]. … to be discussed are HNF1ß, novel genes for ARPKD …
Expression and Characterization of G-protein Coupled Receptor Proteolytic Site of Polycystic Kidney Disease-1 Gene Product
AM Al-sirhani - 2023 - platform.almanhal.com
… polarity, resulting in the formation of renal cysts. The PKD1 gene mutation accounts for …
(GPS) within polycystin-1, a membrane protein with distinct peptide domains implicated in cell-…
(GPS) within polycystin-1, a membrane protein with distinct peptide domains implicated in cell-…
Heterotrimeric G protein signaling in polycystic kidney disease
… , which encodes the polycystin-1 (PC-1) protein, remain the … by heterotrimeric G proteins or
the identification of novel signaling … activation of membrane-associated exchange protein 1/2 (…
the identification of novel signaling … activation of membrane-associated exchange protein 1/2 (…
[HTML][HTML] Emerging therapies for autosomal dominant polycystic kidney disease with a focus on cAMP signaling
X Zhou, VE Torres - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
… the encoded proteins (polycystin-1 and polycystin-2). Polycystin 1 is an adhesion type G
protein … HDAC inhibitor alone or the combination of HDAC inhibitor and tolvaptan may be novel …
protein … HDAC inhibitor alone or the combination of HDAC inhibitor and tolvaptan may be novel …
Newly synthesized polycystin‐1 takes different trafficking pathways to the apical and ciliary membranes
… protein diffusion into the cilium.54, 55 In the case of RP2, a membrane-associated protein that
… We have developed a novel method that allows us to strip the extracellular, noncovalently …
… We have developed a novel method that allows us to strip the extracellular, noncovalently …