… The primary pathology of restless legs syndrome (RLS) may relate to brain iron deficiency
that might induce hyperdopaminergic and hyperglutamatergic states. Such interplay between …

… Restless legs syndrome (RLS) is characterized by an urge to move the legs, usually in …
responsible use for refractory restless legs have been developed 17 ; the use of intravenous iron …

… The severity of impairment from RLS is commonly measured subjectively by rating scales
such as the International Restless Legs Syndrome Study Group rating scale (IRLS) or its self-…

… sensations in the legs with a diurnal variation and a release with movement. The pathophysiology
is … Treatment depends on the severity and frequency of RLS symptoms, comprises non-…

… In the past, the term secondary restless legs syndrome was used in these … The overall quality
of these studies, however, limits the proven association with restless legs syndrome to only …

… the enhancer activity of an restless legs syndrome (RLS)–risk common polymorphism of the
regulatory locus of the gene MEIS1 in the … embryos after injection of the protective (left, “A” for …

… We did a literature search using the PubMed database from its inception to 1 November
2016 and used the broad search term “restless legs syndrome”. We included systematic reviews…

… The first restless legs syndrome (RLS) diagnostic criteria were established in 1995 and
revised in 2003. In 2014, 2 a fifth criterion was added to improve specificity by excluding mimics. …

… factors in the risk of developing restless legs syndrome (RLS) is supported by the high
frequency of positive family history of RLS in patients affected with this disease, and the higher …

… Restless legs syndrome manifests as an overwhelming urge to move the body to relieve
the … Restless legs syndrome affects the patient’s HRQoL to different degrees according to …